Outcomes of Aortic Dissection Repair

Launched by CENTRE CARDIOLOGIQUE DU NORD · Jun 23, 2023

Keywords

ClinConnect Summary

This study (STAAD) is a large, real-world registry that follows adults undergoing surgical repair for acute type A aortic dissection (a serious tear in the chest aorta). It aims to learn how different surgical strategies (such as repairing the ascending aorta alone or with additional arch/root work, or using endovascular or open techniques) and the experience of the treating center affect short-term outcomes (like death within 30 days) and long-term outcomes (up to about 18 years). It’s observational, meaning doctors decide the best approach for each patient and researchers simply collect data on what happens.

If you or a family member might be eligible, you would be adults ages 18 to 90 who have a new acute type A dissection or related problem involving the ascending aorta, with symptoms starting within 7 days, and are undergoing their first surgical repair. Exclusions include being under 18, symptoms starting more than 7 days before surgery, prior dissection surgery, endocarditis, or trauma-related dissection. Participants will have one of several surgical options chosen by their care team, from conservative root-sparing repairs to more extensive aortic replacement, TEVAR, or open repairs. Researchers will collect information during hospital stay and follow patients over time to track outcomes such as 30-day mortality, nerve or kidney problems, bleeding, need for reoperation, and overall survival up to 18 years. The study is led by Centre Cardiologique du Nord with international collaborators and is not regulated by the FDA or testing a new drug.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients aged \> 18 years
• • TAAD or intramural hematoma involving the ascending aorta
• • Symptoms started within 7 days from surgery
• • Primary surgical repair of acute TAAD
• • Any other major cardiac surgical procedure concomitant with surgery for TAAD.
• Exclusion Criteria:
• • Patients aged \< 18 years
• • Onset of symptoms \> 7 days from surgery
• • Prior procedure for TAAD
• • Concomitant endocarditis;
• • TAAD secondary to blunt or penetrating chest trauma.