Deciphering the Vitiligo Transcriptomic Signature Between Repigmented and Non Repigmented Lesions

Launched by UNIVERSITY HOSPITAL, BORDEAUX · Jun 21, 2023

Keywords

ClinConnect Summary

This clinical trial is focused on understanding why some areas of skin affected by vitiligo respond well to treatment while others do not. Vitiligo is a skin condition that causes patches of skin to lose their color. Researchers want to examine the biological processes behind both the repigmented (areas that have regained color) and non-repigmented (areas that have not) lesions. By doing this, they hope to find new ways to improve treatment for everyone with this condition.

To participate in the study, you need to be between 18 and 65 years old and diagnosed with non-segmental vitiligo, which means the patches are symmetrical and cover more than 5% of your body (excluding hands and feet). You should also have new or expanding patches within the last six months. Participants will need to provide consent and be willing to undergo treatment using a combination of oral steroids and light therapy. If you decide to join, you will be closely monitored throughout the study, and your experiences will contribute to a better understanding of vitiligo treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Subject: male or female aged ≥ 18 years and ≤ 65 years
• • Diagnosis of non-segmental (symmetrical) vitiligo with a body surface area involved \>5% excluding hands and feet, with lesions located on arms
• * Active non-segmental vitiligo is defined by:
• • Non-segmental vitiligo with new patches or extension of old lesions during the last 6 months AND
• • Presence of hypochromic aspect under Wood's lamp examination and/or perifollicular hypopigmentation under Wood's lamp examination.
• • Able to read, understand, and give documented informed consent
• • Registered in the French Social Security
• • Patients that could receive the combination of oral steroids and phototherapy according the recommendation
• • Signed informed consent form
• Exclusion Criteria:
• • Segmental or mixed vitiligo
• • Are unable or unwilling to make themselves available for the duration of the study and/or are unwilling to follow study restrictions/procedures.
• • Are currently enrolled in any other clinical trial involving an investigational product or any other type of medical research judged not to be scientifically or medically compatible with this study.