Optimization of MRI Sequences Used in the Study of Neurodegenerative Diseases

Launched by UNIVERSITY HOSPITAL, CAEN · Jun 26, 2023

Keywords

ClinConnect Summary

The trial titled “Optimization of MRI Sequences Used in the Study of Neurodegenerative Diseases” is focused on improving how we use MRI (Magnetic Resonance Imaging) to study memory disorders and other neurodegenerative diseases. The researchers are testing a new, more advanced MRI machine to see if it can provide better images or take less time to capture them. This will help them understand how to better diagnose and study memory issues, particularly in the early stages of these diseases.

Healthy adults between the ages of 65 and 74 who are interested in participating may be eligible, provided they are not pregnant or nursing, do not have certain medical conditions that could interfere with the MRI, and can give informed consent. Participants can expect to undergo MRI scans as part of the study. It's important to note that those with a history of serious brain conditions or who are currently taking specific medications may not be able to join. This study aims to enhance future research and understanding of memory disorders, which could ultimately lead to better care and treatment options.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy volunteers of legal age
• • Affiliation with a social security scheme or beneficiary of such a scheme
• • Signing of the protocol informed consent
• • For women of childbearing age or capacity, a urine pregnancy test before inclusion
• Exclusion Criteria:
• • Protected persons in accordance with articles L. 1121-5 to L.1121-8 of the Public Health Code: protected adults, pregnant and nursing women
• • Presence of contraindications to MRI examination without contrast agents injection
• • Presence of a chronic neurological or psychiatric condition (including substance use disorder)
• • History of brain disease (vascular, degenerative, malformative, tumour, or head trauma with loss of consciousness for more than one hour)
• • Current or recent use of medications that may interfere with imaging (psychotropic drugs, antihistamines with anticholinergic action, antiparkinsonian drugs, benzodiazepines including muscle relaxants, long-term steroidal anti-inflammatory drugs, antiepileptic drugs, central painkillers)