Passive Limb Movement Study

Launched by MEDICAL COLLEGE OF WISCONSIN · Jun 29, 2023

Keywords

ClinConnect Summary

The Passive Limb Movement Study is exploring how different types of leg movements affect blood flow in stroke survivors. After a stroke, many people experience reduced blood circulation in their legs, which can lead to additional health issues like another stroke or heart disease. This study aims to see if a technique called ischemic conditioning, which temporarily restricts blood flow, can help improve blood circulation during both passive leg movements (where the legs move without the person actively trying) and active leg movements (where the person intentionally contracts their leg muscles).

To participate in this study, you need to be between 18 and 85 years old and have had a stroke at least six months ago, with some ongoing effects like weakness on one side of your body. The study is also looking for healthy adults of various ages to compare results. If you join, you can expect to undergo some tests to measure how your blood flow responds to movement. It’s important to know that there are certain health conditions that might prevent you from participating, so it’s essential to discuss your medical history with the research team.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Individuals Post-Stroke
• • 18 - 85 years of age
• • Cortical or sub-cortical stroke ≥ 6 months ago with residual hemiparesis
• • Able to give informed consent and follow 2-step command.
• • English Speaking
• • Age- and Sex-Matched Controls (CON)
• • Matched to age of individual post- stroke ± 5 years.
• • Matched to sex of individual post-stroke
• • Able to give informed consent and follow 2-step command.
• • English Speaking
• • Young Healthy Adults (CONyoung)
• • Age 18-30 years old
• • Able to give informed consent and follow 2-step command.
• • English Speaking
• Exclusion Criteria:
• • All Groups
• • Unable to stand from chair and walk 10 meters without physical assistance from another person (able to use assistive device).
• • History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (i.e., wounds in the leg).
• • Chronic lasting symptoms (\> 6 months) of severe COVID-19 (i.e., hospitalization)
• • Low back or hip pain that limits lower extremity motor testing.
• • History of head trauma or concussion within the past 6 months
• • Comorbid neurological disorder
• • Peripheral vascular disease
• • Myocardial infarction in the previous year
• • Condition where fatiguing contractions or resisted leg contractions are contraindicated
• • Resting SBP ≥180 mmHg or DBP ≥ 100 mmHg
• • Pregnancy or breastfeeding.
• • Other significant medical condition likely to influence study or jeopardize safety as assessed by the Primary Investigator
• • CON and CONyoung
• • History of Stroke