Exploration of Allograft Humoral Rejection in Chronic Histiocytic Intervillositis

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Jun 30, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a rare condition called chronic histiocytic intervillositis (CHI), which can cause serious problems during pregnancy, like poor growth of the baby, stillbirth, and miscarriages. Researchers believe that the immune system might be reacting against the baby, similar to how the body rejects a transplanted organ. By understanding this immune response better, the trial aims to find new ways to predict and potentially reduce the risk of losing a baby for mothers who have experienced complications related to CHI.

To be eligible for this trial, mothers must be at least 18 years old and have a history of either normal pregnancies or complications like IUGR (intrauterine growth retardation), stillbirth, or miscarriages. Fathers must also be involved in the study. Participants will help researchers gather information and samples from past pregnancies to better understand CHI and its effects. If you or someone you know fits these criteria, this trial could contribute to important research that may help improve outcomes for future pregnancies.

Gender

ALL

Eligibility criteria

• Family Inclusion Criteria:
• • Mother and father ≥ 18 years old
• * For mothers in the CHI group :
• • History of a normal pregnancy (full term, alive child) or IUGR/MFIU or miscarriage(s) or abortion followed by at least 1 obstetrical complication such as IUGR, MFIU, miscarriage
• • Diagnosis of chronic histiocytic intervillitis made by placental anatomopathological examination with CD68+ marking
• • For the mothers of the antiphospholipid syndrom group
• • History of miscarriage(s)
• • Having an anti-phospholipid syndrome
• * For mothers in the normal pregnancy group:
• • Third consecutive pregnancy of normal course, at term (≥ 36 weeks of amenorrhea) with eutrophic child
• For the mother and father:
• • o Consent to participate in the study and for the participation in the study of at least one child and/or the use of existing samples (placenta / fetal DNA) from at least one previous pregnancy with CHI for the CHI group or at least one previous miscarriage for the APS group
• For the father:
• • o Father of the last pregnancy and of the child(ren) participating in the study
• Exlusion criteria :
• * For mothers in the normal pregnancy group:
• • o Suspected or confirmed intra-amniotic infection
• * For all the mothers:
• • History of blood transfusion
• • History of allogeneic organ transplantation
• * For the mother and the father:
• • Person under legal protection (guardianship, curatorship)