Hemodynamic Responses of Dexmedetomidine, Lidocaine or Propofol Infusions During Laparoscopic Cholecystectomy

Launched by MENOUFIA UNIVERSITY · Jul 5, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how different medications—dexmedetomidine, lidocaine, and propofol—affect the body’s responses during a specific type of surgery called laparoscopic cholecystectomy, which is the removal of the gallbladder. The researchers want to see which of these medications helps keep blood pressure and heart rate stable when doctors use a technique called pneumoperitoneum, where gas is introduced into the abdomen to create space for the surgery.

To participate in this study, you need to be between 20 and 60 years old and generally healthy, as determined by your doctor. However, if you have certain health conditions, like diabetes, high blood pressure, liver or kidney problems, or if you are taking specific medications, you may not be eligible. If you join the trial, you will receive one of the three medications during your surgery, and the medical team will monitor how well your body responds. This trial is currently recruiting participants, and it aims to help improve anesthesia practices for surgeries like this in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • American Society of Anesthesiologists I patients.
• • Patients between the ages of ≥ 20 and ≤ 60 years of both sexes.
• Exclusion Criteria:
• • Hypersensitivity to dexmedetomidine, propofol or lidocaine.
• • Diabetic patients (Hemoglobin A1C ≥ 7).
• • Hypertensive patients (Blood presssure ≥ 140/90 mmHg) or patients on medications that affect hemodynamics as clonidine, methyldopa, β blockers and calcium channel blockers.
• • Impaired liver function (serum albumin ≤ 3.5 g/dl, International normalized ratio≥ 1.3, total bilirubin \>1mg/dl).
• • Impaired renal function (serum creatinine \>1.2 mg/dl, blood urea \>20mg/dl).
• • Morbidly obese patients with body mass index ≥ 40.
• • Patients with acute cholecystitis or active infection.
• • Patients taking medications that may impair cognition.
• • History of seizures.