Effects of Flumazenil on Recovery After Total Intravenous Anesthesia With Remimazolam

Launched by PUSAN NATIONAL UNIVERSITY YANGSAN HOSPITAL · Jul 2, 2023

Keywords

ClinConnect Summary

This clinical trial is investigating the effects of a medication called flumazenil on patients recovering from surgery using another medication called remimazolam. Remimazolam is known for its quick effects and the ability to reverse sedation with flumazenil if needed. The study aims to find out whether using flumazenil routinely after surgery is necessary when remimazolam has been used for anesthesia.

To participate in this trial, patients need to be at least 65 years old and scheduled for hip joint surgery. However, there are some important conditions that would exclude someone from joining, such as having unstable health before surgery or a history of certain neurological issues. Participants can expect to receive care and monitoring as part of the study, and their recovery will be assessed to see how the medications affect them. This trial is currently looking for volunteers, and their insights could help improve recovery processes for elderly patients undergoing surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients over 65 years old scheduled for hip joint surgery
• Exclusion Criteria:
• • Patients with impaired consciousness or delirium before surgery
• • Patients who are hemodynamically unstable before surgery
• • Patients with a history of neurological or neuromuscular disorders or use of medications that affect neurological or neuromuscular function
• • Patients who have taken sedatives (anti-anxiety medications, antipsychotics, antidepressants, sleep aids) within the past 24 hours
• • Patients with known allergy to benzodiazepine, flumazenil
• • Patients with galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption
• • Patients with hypersensitivity to Dextran40
• • Patients who have been taking benzodiazepine for long term
• • Patients with end stage renal disease requiring hemodialysis
• • Patients with history of acute angle glaucoma
• • Patients with alcohol or substance dependence
• • ASA classification 4 or 5