Prophylactic Use of Tamsulosin in the Prevention of Post-operative Urinary Retention in Men After Rectum Resection

Launched by CHU DE QUEBEC-UNIVERSITE LAVAL · Jul 4, 2023

Keywords

ClinConnect Summary

This clinical trial is studying whether a medication called tamsulosin can help prevent urinary retention in men after they have surgery to remove part of the rectum, a procedure known as rectal resection. Urinary retention means having trouble emptying the bladder, which can be a common problem after this type of surgery. The trial will compare men who receive tamsulosin with those who get a placebo, which is a harmless pill with no active ingredients, to see if tamsulosin can reduce the chances of this issue and other related complications.

To participate in this study, men aged 18 and older who are scheduled for rectal resection may be eligible, but there are some important criteria. For example, men who have had previous urinary surgeries or are currently using certain medications that could interact with tamsulosin cannot join the trial. Participants will be closely monitored during their hospital stay, and the study will look at how long they need to stay in the hospital, how many times they need to have a catheter (a tube used to help empty the bladder), and how long that catheter stays in place. This trial aims to improve recovery for men undergoing this surgery by potentially reducing urinary problems.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Male patients
• • 18 years and older
• • Scheduled for rectal resection during the study period.
• Exclusion Criteria:
• • Patients undergoing revisional surgery
• • Patients taking alpha-blocker medication,
• • Patients who have an indwelling urinary catheter,
• • Patients who have undergone urinary tract surgery,
• • Patients who will have an intraoperative trauma of the urinary tract,
• • Patients who will keep their urinary catheter for more than 24 hours after surgery,
• • Patients who have an intolerance to alpha-blocking drugs or who take one of the following drugs (potential interaction): anti-retroviral, antifungal, clarithromycin, erythromycin, paroxetine, terbinafine, cimetidine, coumadin or phosphodiesterase inhibitors.
• • Patients who will have an epidural anesthesia