Clinical Study of Ligustrazine in Treating Alcohol Addiction

Launched by SHENZHEN KANGNING HOSPITAL · Jul 4, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a medication called ligustrazine to see if it can help people struggling with alcohol addiction. Alcohol abuse can lead to serious health problems, including heart disease and cancer, and current treatments are not always effective. The researchers believe that ligustrazine might work better because it acts on different parts of the brain involved in alcohol dependence. The goal is to find new ways to treat alcohol addiction and improve patient care.

To be eligible for this study, participants need to be between 18 and 65 years old and diagnosed with alcohol dependence. They should not have serious neurological issues or a family history of mental illness. If someone is interested, they can expect to take the medication and undergo brain imaging to help understand how ligustrazine works. It's important to note that certain conditions may exclude someone from participating, such as being in withdrawal from alcohol or having severe mental health issues. Overall, this trial aims to provide better treatment options for those affected by alcohol addiction.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• 1. Alcohol addiction:
• • ①Aged 18\~65 years old;
• • ② Meet the diagnostic criteria of DSM-IV alcohol dependence;
• • ③No clear history of neurological diseases in the past, no family history of mental diseases;
• • ④Voluntary participation in research, with good follow-up and observation, and good compliance;
• • ⑤ No obvious psychotic symptoms.
• • 2. Combined with the therapeutic indications of ligustrazine, selected cases must meet any of the following criteria on the premise of normal coagulation routine (no bleeding tendency): D-2 polymer ≥500 (thrombotic tendency) or atherosclerosis index ≥4 or one or more blood lipid indicators (TC, HDL, LDL) are abnormal.
• • Arteriosclerosis index (AI) = \[total cholesterol (TC) - high-density lipoprotein (HDL)\] ÷ high-density lipoprotein (HDL), the normal value of AI is \<4, reflecting that the degree of arteriosclerosis is not serious or mild, The smaller the value, the lighter the degree of arteriosclerosis. If the arteriosclerosis index ≥ 4, it means that obvious arteriosclerosis has occurred, and the larger the value, the more serious the degree of arteriosclerosis.
• Exclusion Criteria:
• • ① Acute alcohol withdrawal phase, CIWA-Ar \> 9 points;
• • Severe neurological or mental diseases caused by diseases other than chronic alcohol dependence: such as stroke, intracranial infection, brain tumor, schizophrenia, etc.;
• • Have experienced traumatic brain injury or other damage to brain tissue; ④ Taking any other psychotropic drugs, drug use or other substance dependence in the short term; ⑤ There are contraindications to the application of ligustrazine, or women are pregnant and other conditions that are not suitable for drug use; ⑥ There are conditions that are not suitable for head MRI examination, such as claustrophobia, metal objects in the body, etc.