Substantiation and Standardization of the Multimodal Cognitive-motor Rehabilitation System for Afterstroke Patients

Launched by MOSCOW SCIENTIFIC AND PRACTICAL CENTER OF MEDICAL REHABILITATION, RESTORATIVE AND SPORTS MEDICINE · Jul 6, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new rehabilitation program designed for people recovering from a stroke. The goal is to create a standardized system that combines cognitive training and physical exercises to help patients improve their recovery. The program will be tailored to meet individual needs based on how well patients are doing and at what stage they are in their recovery.

To participate, you must be between 45 and 70 years old and have had your first stroke recently or in the past year. You should have some movement difficulties in your arms and legs but still have enough strength and cognitive ability to follow the program. If you meet these criteria, you can expect to take part in exercises and activities that could help your recovery. It's important to note that certain medical conditions, like severe heart problems or other neurological diseases, may prevent you from joining the trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Men or women aged 45 to 70 years after a first-onset IS, acute (1-21 days), early (22 days- 6 months), late recovery (6-12 months) periods.
• • Supratentorial IS according to MRI of the brain.
• • The severity of UL and LL paresis ranged from a score of 4 to 2 according to the Medical Research Council Scale (MRCS)
• • Spasticity of 3 points or less by the Modified Ashworth Scale (MAS)
• • Cognitive function more than 20 points on the Montreal Cognitive Assessment (MoCA)
• • Affective disorders score less than 11 on the Hospital Anxiety and Depression Scale (HADS)
• • The patient's ability and willingness to comply with the requirements of this protocol.
• Exclusion Criteria:
• • 1. Concomitant neurological diseases causing decreased muscle strength or increased muscle tone in the UL (e.g., cerebral palsy, brain injury).
• • 2. Clinically significant limitation of the passive movement amplitude in the joints of the investigated hand, pronounced contracture and deformities of the upper extremity.
• • 3. Use of other DIT, BFB techniques to restore impaired UL function within 30 days prior to the patient Inclusion Visit.
• • 4. Severe visual impairment, decreased visual acuity of less than 0.2 in the worst eye according to the Golovin-Sivtsev Table24.
• • 5. Sensory aphasia, gross motor aphasia.
• • 6. Recurrent stroke.
• • 7. Epilepsy
• • 8. Unstable angina and/or heart attack in previous month.
• • 9. Uncontrolled arterial hypertension.
• • 10. Somatic diseases in decompensation stage.
• • 11. Thrombosis of deep and superficial veins of the lower extremities
• • 12. The presence of left-handedness in the patient according to the Edinburgh manual asymmetry questionnaire
• • 13. Alcohol abuse, medical marijuana use or soft drug abuse within the 12 months prior to the Inclusion Visit.
• • 14. Any medical condition, including mental disease or epilepsy that could affect the interpretation of study results, the study procedures or patient safety.
• • 15 Pregnancy. 16. Lactation.