Prehabilitation Program to Improve Cardiac Reserve in High-Risk Patients Undergoing Hematopoietic Stem Cell Transplantation

Launched by UNIVERSITY OF MICHIGAN ROGEL CANCER CENTER · Jul 6, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at a special program called Cardio-Oncology Prehabilitation, which aims to help patients who are at high risk of heart problems improve their heart and lung fitness before undergoing a treatment called Hematopoietic Stem Cell Transplantation (HSCT). The goal is to see if this program can help patients feel better and reduce the chances of heart-related issues during and after their transplant.

To participate in this study, you need to be an adult aged 18 or older who has been referred for an HSCT evaluation and has at least one risk factor for heart disease, such as high blood pressure or diabetes. If you decide to join, you will undergo assessments and possibly participate in exercises to improve your fitness. It's important to note that individuals with certain severe heart conditions or those who cannot move independently may not be eligible. The trial is currently recruiting participants, and everyone who joins will receive guidance and support throughout the process.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult 18 years or older
• • Referred for HSCT evaluation
• • Presence of least one CV risk factor at enrollment (hypertension, hyperlipidemia, atrial fibrillation, obesity, heart failure, history of coronary artery disease, diabetes)
• • Able to ambulate unassisted
• • Ability to understand and the willingness to sign a written informed consent
• • Ability to use Polar Flow heart rate application
• Exclusion Criteria:
• • Severe anemia (hemoglobin \<7 gm/dl)
• • Untreated high-risk coronary artery disease (left main, triple vessel disease)
• • Severe aortic stenosis
• • Recent fracture as assessed via self-report
• • Gross balance deficits
• • Severe pain with basic movement
• • Unable to ambulate unassisted or exercise
• • NYHA class IV heart failure
• • Adults unable to give consent, pregnant women, and prisoners are excluded from this study.