Oxymetazoline Drops for Acquired Blepharoptosis From Synkinesis

Launched by MILTON S. HERSHEY MEDICAL CENTER · Jul 6, 2023

Keywords

ClinConnect Summary

Broadly, synkinesis is a neuromuscular condition in which voluntary muscle contraction causes simultaneous involuntary contraction of other muscle groups e.g. pursing of the lips causes involuntary closure of the eye. It is a common sequelae of facial nerve paralysis with 55% or more of patients reporting synkinetic facial movement. 2 Additionally, patients may develop hyperkinesis due to continual firing of nerves that have aberrantly regenerated, thereby causing decreased movement due to antagonistic muscle hyperactivity, tightness, spasms, and pain. These together significant affect faci...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Over 18 years of age
• • 2. Primary diagnosis of nonflaccid facial paralysis (aberrant regeneration syndrome) and acquired blepharoptosis.
• Exclusion Criteria:
• • 1. Patients under the age of 18
• • 2. Patients on cardiac glycosides
• • 3. Patients on MAO inhibitors
• • 4. Patients with angle closure glaucoma
• • 5. Patients who experience asymmetrical eye opening due to weakness (e.g. lagophthalmos).