DESTINY Breast Respond HER2-low Europe
Launched by DAIICHI SANKYO EUROPE, GMBH, A DAIICHI SANKYO COMPANY · Jul 6, 2023
Trial Information
Current as of August 27, 2025
Recruiting
Keywords
ClinConnect Summary
The DESTINY Breast Respond HER2-low Europe trial is studying a new treatment called trastuzumab deruxtecan (T-DXd) for adults with advanced breast cancer that is HER2-low expressing. This means the cancer cells have a lower level of a specific protein called HER2, which can affect how the cancer grows. The trial is looking for participants who have already received chemotherapy and either have cancer that cannot be surgically removed or have experienced a recurrence of their cancer within six months of finishing their last treatment.
To be eligible for this trial, participants must be at least 18 years old and have a confirmed diagnosis of unresectable (unable to be removed) or metastatic (spread to other parts of the body) breast cancer. They also need to have documented HER2-low status. If you join the trial, you will receive the T-DXd treatment, and your health will be closely monitored by the research team. It’s important to note that pregnant or breastfeeding individuals cannot participate, and those currently involved in another clinical study that is not open can also not take part. This trial aims to see if T-DXd can provide a new treatment option for patients with this specific type of breast cancer.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Adult patient (age ≥ 18 years) with histological or cytological confirmed diagnosis of unresectable and/or mBC
- • Documented HER2-low status (IHC1+, IHC2+/ISH-)
- • Patients who have received prior chemotherapy in the metastatic setting or patients who have developed disease recurrence during or within 6 months of completing adjuvant chemotherapy
- • Decision to newly initiate therapy of T-DXd or conventional chemotherapy according to the physicians choice per SmPC
- • Written and signed Informed Consent to participate in the study
- Exclusion Criteria:
- • Pregnancy or breastfeeding
- • Patients who at time of data collection for this study are participating in or have participated in an interventional study that remains blinded.
- • No specific exclusion criteria are defined, as patients will be treated according to the proposed indication statements in the SmPC.
About Daiichi Sankyo Europe, Gmbh, A Daiichi Sankyo Company
Daiichi Sankyo Europe GmbH, a subsidiary of Daiichi Sankyo Company, is a leading global pharmaceutical organization dedicated to the research, development, and commercialization of innovative medicines. With a strong focus on addressing unmet medical needs, the company leverages its expertise in pharmaceuticals and biotechnology to advance therapies in oncology, cardiovascular diseases, and other therapeutic areas. Committed to enhancing patient outcomes through scientific excellence and collaboration, Daiichi Sankyo Europe GmbH plays a pivotal role in driving clinical trials and bringing transformative treatments to market in Europe and beyond.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Brussels, , Belgium
Clermont Ferrand, , France
Rennes, , France
Madrid, , Spain
Paris, , France
Chieti, , Italy
Madrid, , Spain
Madrid, , Spain
Madrid, , Spain
Santander, , Spain
Herlev, , Denmark
Limoges, , France
Paris, , France
Cordoba, , Spain
Créteil, , France
Wels, , Austria
Lille, , France
Troyes, , France
Zürich, , Switzerland
Rouen, , France
Brussels, , Belgium
Wien, , Austria
Suresnes, , France
Wien, , Austria
Lausanne, , Switzerland
Pavia, , Italy
Brasschaat, , Belgium
Graz, , Austria
Innsbruck, , Austria
Naestved, , Denmark
Reims, , France
La Laguna, , Spain
Rouen, , France
Aalst, , Belgium
Elche, , Spain
La Louviere, , Belgium
Lyon, , France
Antony, , France
Palma, , Spain
Aarhus N, , Denmark
Baden, , Switzerland
Caen, , France
Wien, , Austria
Poitiers, , France
Pau, , France
Valladolid, , Spain
Amiens, , France
Wiener Neustadt, , Austria
Dechy, , France
Bonheiden, , Belgium
Lyon, , France
Skien, , Norway
Liestal, , Switzerland
Arras, , France
Valenciennes, , France
Lille, , France
Ottignies, , Belgium
Niort, , France
Barakaldo, , Spain
Valladolid, , Spain
San Giovanni Rotondo, , Italy
St. Gallen, , Switzerland
Hasselt, , Belgium
Sion, , Switzerland
Cholet, , France
Jönköping, , Sweden
Barcelona, , Spain
Napoli, , Italy
Linz, , Austria
Vannes, , France
Montpellier, , France
Nice, , France
Novara, , Italy
Dijon, , France
Bordeaux, , France
Macerata, , Italy
Salzburg, , Austria
Klagenfurt Am Wörthersee, , Austria
Sabadell, , Spain
Vandœuvre Lès Nancy, , France
Alzira, , Spain
Le Puy En Velay, , France
León, , Spain
Taormina, , Italy
Galdakao, , Spain
Amiens, , France
Toulon, , France
Liège, , Belgium
Torino, , Italy
La Chaussee Saint Victor, , France
Bourg En Bresse, , France
Palencia, , Spain
Cáceres, , Spain
Valencia, , Spain
Bayonne, , France
Madrid, , Spain
Reims, , France
Sant Cugat Del Vallès, , Spain
Chalon Sur Saône, , France
Madrid, , Spain
Bayonne, , France
Vöcklabruck, , Austria
Namur, , Belgium
Bilbao, , Spain
Villeurbanne, , France
Sint Niklaas, , Belgium
Chambéry, , France
Padova, , Italy
Neuilly Sur Seine, , France
Sarcelles, , France
Gävle, , Sweden
Monza, , Italy
Chambray Lès Tours, , France
Rankweil, , Austria
Salzburg, , Austria
Brugge, , Belgium
Haine Saint Paul, , Belgium
Liege, , Belgium
Verviers, , Belgium
Aalborg, , Denmark
Sønderborg, , Denmark
Avignon, , France
Besançon, , France
Compiègne, , France
Fort De France Cedex, , France
Fréjus, , France
Grenoble, , France
La Tronche, , France
Le Mans, , France
Lille, , France
Metz, , France
Montivilliers, , France
Neuilly Sur Seine, , France
Nîmes Cedex 9, , France
Paris, , France
Paris, , France
Saint Cloud, , France
Saint Paul, , France
Sens Cédex, , France
Thionville, , France
Valence, , France
Alessandria, , Italy
Città Di Castello, , Italy
Empoli, , Italy
Lecco, , Italy
Legnago, , Italy
Meldola, , Italy
Palermo, , Italy
Potenza, , Italy
Roma, , Italy
Roma, , Italy
Salerno, , Italy
Torino, , Italy
Udine, , Italy
Varese, , Italy
Tromsø, , Norway
Albacete, , Spain
Cádiz, , Spain
Granada, , Spain
Lugo, , Spain
Murcia, , Spain
Oviedo, , Spain
Palma De Mallorca, , Spain
Pontevedra, , Spain
Reus, , Spain
Vigo Pontevedra, , Spain
Stockholm, , Sweden
Stockholm, , Sweden
Västerås, , Sweden
örebro, , Sweden
Frauenfeld, , Switzerland
Fribourg, , Switzerland
Genève, , Switzerland
Zürich, , Switzerland
Jaén, , Spain
Leoben, , Austria
Auderghem, , Belgium
Hillerød, , Denmark
Levallois Perret, , France
Lecce, , Italy
Legnano, , Italy
Modena, , Italy
Palermo, , Italy
Pisa, , Italy
Reggio Calabria, , Italy
Reggio Emilia, , Italy
Sassari, , Italy
Treviso, , Italy
Bodø, , Norway
Drammen, , Norway
Kristiansand, , Norway
Logroño, , Spain
Eskilstuna, , Sweden
Sundsvall, , Sweden
La Chaux De Fonds, , Switzerland
Lausanne, , Switzerland
Umeå, , Sweden
Patients applied
Trial Officials
Global Team Leader
Study Director
Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported