Spectral Characteristics of Memory Transformation

Launched by MEDICAL UNIVERSITY OF SOUTH CAROLINA · Jul 7, 2023

Keywords

ClinConnect Summary

The clinical trial titled "Spectral Characteristics of Memory Transformation" is exploring how we can change or unlearn certain movements, like a bad golf swing or incorrect piano posture, especially when these movements cause problems like chronic pain or hinder recovery after a stroke. Researchers will use a safe technique called electroencephalography (EEG) to study the brain's activity while trying to modify these established movement memories. They will also apply non-invasive brain stimulation to see if it helps people learn new motor skills more effectively.

To participate, you need to be at least 18 years old, with a majority of participants being over 60. You should not have had a stroke or any significant head injuries, and you must be able to use a computer and give consent to join the study. If you decide to participate, you can expect to engage in activities that involve learning and practicing new movements while the researchers monitor your brain activity. It's important to note that certain medical conditions and medications may exclude you from the study, so it’s best to check with your doctor if you have any concerns.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 18 years or older (2/3 of the final sample will be ≥60years of age)
• • No previous stroke, brain tumor, neurodegenerative disease, or trauma to the head
• • Ability to give consent for study participation
• • who have access to a personal computer with internet
• Exclusion Criteria:
• • • Pregnancy
• • Inability to use all ten fingers to type on a standard computer keyboard
• • Uncorrected vision, hindering perception of visual cues presented on a standard computer screen
• • Medication use at the time of study that may interfere with learning or the effect of tACS, including but not limited to carbamazepine, flunarizine, sulpiride, rivastigmine, dextromethorphan;
• • Neuromuscular disorders affecting hand and finger movements necessary for 10-finger keyboard typing
• • Presence of neurological or psychiatric disorders
• • Presence of scalp injury or disease
• • Prior history of seizures
• • Prior intracranial surgery
• • Prior brain radiotherapy
• • Prior history of intracranial tumor, intracranial infection, or cerebrovascular malformation
• • Metal in head or neck
• • Contraindications to MRI (such as severe claustrophobia, implanted medical devices)