Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes

Launched by ANNA STANHEWICZ, PHD · Jul 7, 2023

Keywords

ClinConnect Summary

This clinical trial is looking into how oxidative stress, which is an imbalance between free radicals and antioxidants in the body, affects small blood vessel function in women who have had gestational diabetes (GDM). The researchers want to understand why some women might have trouble with their blood vessels after experiencing GDM, even if they are otherwise healthy.

To participate in the study, women must be between 18 and 50 years old, have had a pregnancy within the last five years, and either have a history of gestational diabetes or none at all. However, certain conditions like skin diseases, current pregnancy, or use of specific medications may exclude someone from joining. Participants can expect to engage in tests that measure their blood vessel health and oxidative stress levels. This study is currently recruiting participants, and it aims to help improve understanding and care for women with a history of gestational diabetes.

Gender

FEMALE

Eligibility criteria

• INCLUSION CRITERIA:
• • female sex
• • 18 -50 years old
• • pregnancy history within 5 years of the study visit
• • had gestational diabetes diagnosed by their obstetrician and confirmed according to the American College of Obstetricians and Gynecologists criteria for gestational diabetes
• • or without a history of gestational diabetes
• EXCLUSION CRITERIA:
• • skin diseases
• • current tobacco/e-cigarette use
• • diagnosed or suspected hepatic or metabolic disease including diabetes
• • statin or other cholesterol-lowering medication
• • current antihypertensive medication
• • history of preeclampsia or gestational hypertension
• • current pregnancy
• • body mass index \<18.5 kg/m2
• • allergy to materials used during the experiment.(e.g. latex), known allergies to study drugs.