Alternative Gingival De-Epithelialization Techniques

Launched by UNIVERSITY OF MICHIGAN · Jul 12, 2023

Keywords

ClinConnect Summary

Participants will be randomly assigned to one of four surgical techniques during their surgical procedure and the wound site will be assessed on post-operative days 1, 7, 14, and 21.

Researchers will compare the use of mucotome, Er:YAG laser, surgical diamond bur, or blade to observe patterns of wound healing and assess if one method is superior in terms of removing the epithelium.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • American Society of Anesthesiologists (ASA) Physical Status Classification I or II
• • Subjects undergoing periodontal surgical procedures that involve harvesting of soft tissue samples, who have a treatment plan including the use or removal of keratinized mucosa or subepithelial connective tissue that will not require additional anesthesia for sample collection
• • Adequate physical and mental health to undergo routine dental treatment
• • Ability and willingness to follow instructions related to the study procedures
• Exclusion Criteria:
• • Poorly controlled diabetes, defined as HbA1c \>/= 7.0
• • Autoimmune or inflammatory conditions such as systemic lupus erythematous, rheumatoid arthritis.
• • Pregnant women or nursing mothers, or unsure of pregnancy status (self-reported)
• • Severe hematologic disorders, such as leukemia or hemophilia
• • Subjects on anticoagulant or antiplatelet therapy
• • Local or systemic infection that may interfere with healing
• • Hepatic or renal diseases
• • Currently under cancer treatment or within 18 months from completion of radio- or chemotherapy
• • History of antibiotic or immunosuppressant use in the last 3 months
• • Subjects on concomitant drug therapy for systemic conditions that may affect outcomes of the study
• • Current smokers (CDC definition): heavy smokers: subjects who have smoked \>10 cigarettes per day within 6 months of study onset, and have smoked \>100 cigarettes in their lifetime