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Search / Trial NCT05950607

Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0

Launched by HEBREW SENIORLIFE · Jul 10, 2023

Trial Information

Current as of October 25, 2025

Recruiting

Keywords

ClinConnect Summary

This clinical trial is studying how to manage infections in nursing home residents who have dementia, including Alzheimer’s disease. The researchers want to find out if using a special approach to care can help these residents use fewer antibiotics and avoid unnecessary medical procedures compared to the usual care they receive. This trial is currently recruiting participants, and it aims to improve the quality of care for people living with dementia in nursing homes.

To be eligible for this study, participants need to be at least 60 years old, diagnosed with any type of dementia, and have been living in a nursing home for more than 90 days. They should also have a cognitive functional score that indicates at least mild cognitive impairment. If someone joins the trial, they will receive either the new approach to infection management or the standard care currently provided. Overall, this research aims to make healthcare for nursing home residents with dementia safer and more effective.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • 1. Age \> 60
  • 2. A diagnosis of dementia (any type)
  • 3. Cognitive Functional Scale (CFS) \> 1
  • 4. NH length of stay \>90 days
  • The CFS score categorizes cognitive impairment status based on data in the electronic health record into: 1. None, 2. Mild, 3. Moderate, and 4. Severe (advanced). For the primary outcome, the analysis will be restricted to residents with a CFS score of 3 or 4.
  • Exclusion Criteria:
  • 1. Less than 60 years of age
  • 2. Living in nursing home for less than 90 days
  • 3. Does not have diagnosis of dementia
  • 4. Does not meet CFS \>1 score

About Hebrew Seniorlife

Hebrew SeniorLife is a distinguished nonprofit organization dedicated to enhancing the quality of life for older adults through innovative research, comprehensive healthcare services, and community engagement. As a leader in geriatric care, Hebrew SeniorLife conducts clinical trials aimed at advancing medical knowledge and improving treatment options for age-related conditions. With a commitment to excellence, the organization collaborates with academic institutions and healthcare providers to ensure that its research is grounded in the highest ethical standards and scientific rigor. Through its focus on the unique needs of seniors, Hebrew SeniorLife strives to foster healthier, more fulfilling lives for the aging population.

Locations

Boston, Massachusetts, United States

Patients applied

0 patients applied

Trial Officials

Susan Mitchell, MD, MPH

Principal Investigator

Hebrew SeniorLife

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported