Quantifying Artificial Pancreas-related Changes in Diabetic Neuropathy

Launched by MANCHESTER UNIVERSITY NHS FOUNDATION TRUST · Jul 10, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring how insulin pump therapy and automated insulin delivery (also known as the Artificial Pancreas) might help improve nerve damage, or neuropathy, in people with type 1 diabetes. Neuropathy can cause painful symptoms and lead to serious complications like foot ulcers and infections. Currently, there are no approved treatments to reverse neuropathy, so managing blood sugar levels is crucial to prevent it from getting worse. The researchers believe that using these newer insulin delivery methods could stabilize blood sugar levels better than traditional insulin injections, potentially easing the symptoms of neuropathy and even aiding in nerve recovery.

To participate in the trial, individuals must be aged 18 to 70, have type 1 diabetes, and either be starting an Artificial Pancreas or insulin pump therapy, or currently be on multiple daily insulin injections. Participants will undergo various assessments to measure their nerve health and symptoms. This study is not yet recruiting, but if successful, it could provide important evidence that might lead to better treatment options for patients with diabetic neuropathy.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Type 1 diabetes aged 18-70 who falls into either of these three categories and has the ability to read and comprehend English:
• • Starting Artificial Pancreas therapy as determined for clinical need Starting insulin pump therapy as determined for clinical need On multiple daily injection therapy for insulin delivery
• Exclusion Criteria:
• • History of ocular disease that may affect the cornea.
• • History of corneal trauma or surgery (NB cataract surgery does not preclude enrolment unless surgery occurred in the 3 months prior to enrolment date)
• • Concurrent ocular disease, infection or inflammation.
• • History of neuropathy due to alcoholism, renal impairment requiring renal replacement therapy, infectious disease (e.g., Lyme disease, HIV/AIDS, hepatitis B), liver failure, B12 deficiency
• • Unable to read and comprehend English