Maternal Endocrine System and Metabolic Diseases and Offspring Health: Prediction Within a Birth Cohort

Launched by PEKING UNION MEDICAL COLLEGE HOSPITAL · Jul 17, 2023

Keywords

ClinConnect Summary

This clinical trial is focused on understanding how maternal health conditions, like thyroid problems and diabetes, affect the health of children. Researchers are noticing that these metabolic diseases are becoming more common among pregnant women, and they want to find ways to predict and potentially prevent these issues in children. By collecting health data from pregnant women and following them over time, the study aims to create a system that can alert healthcare providers about potential risks to the baby’s metabolism early on.

To participate in this trial, pregnant women who can give their consent are welcome. However, those expecting twins or facing serious pregnancy complications, as well as women with certain pre-existing health conditions or those who have had specific surgeries, will not be eligible. Participants can expect to provide health information and biological samples, which will help build a database that could lead to better prevention and treatment strategies for metabolic diseases in both mothers and their children. This research is particularly important in addressing the rising rates of conditions like diabetes and obesity in China.

Gender

ALL

Eligibility criteria

• lnclusion Criteria:
• • Pregnant women
• • Voluntary signing of informed consent
• Exclusion Criteria:
• • Twin or multiple pregnancy
• • Severe pregnancy complications
• • Complicated with important heart, liver, kidney, blood system and autoimmune diseases before pregnancy
• • Associated with other diseases that may affect intestinal flora or metabolomics, including inflammatory bowel disease, irritable bowel syndrome, celiac disease, etc.
• • Gastrointestinal and biliary surgeries, including bariatric surgery and cholecystectomy
• • History of smoking, alcoholism, narcotic drug use
• • For women who keep stool samples: antibiotics within 2 months of specimen collection: probiotics within 1 week of specimen collection: take oral drugs that may affect intestinal flora.