High Relaxivity Contrast Agent for Cardiac MR in the Myocardial Scar Assessment

Launched by JOHNS HOPKINS UNIVERSITY · Jul 13, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new contrast agent called Elucirem (Gadopiclenol) for use in cardiac MRI scans, specifically to assess myocardial fibrosis, which is a condition that can cause scarring in the heart muscle. The researchers want to find out if a lower dose of Elucirem is just as effective as a higher dose of another contrast agent, Dotarem, when it comes to identifying heart scars. This trial is important because Elucirem has shown a lot of promise in other areas, but its effectiveness in cardiac imaging still needs to be confirmed.

To participate in this trial, you must be at least 21 years old, weigh less than 120 kg, and have healthy kidney function. You also need to be comfortable undergoing an MRI scan and not have any conditions that would make the scan unsafe, such as certain medical devices or a history of allergic reactions to gadolinium-based contrast agents. Participants will come from a previous study and will have the opportunity to receive either a lower dose of Elucirem or a higher dose of Dotarem in a safe and controlled setting. If you qualify and choose to join, you will help researchers understand how well this new agent works for heart imaging, which could lead to better diagnosis and treatment for heart conditions in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participants from previous double-dose Doatrem CMR study who are willing to participate and sign the consent will be enrolled in this study. Participants must be ≥21 years old, less than 120kg, not claustrophobic, and eGFR be 60 and more.
• Exclusion Criteria:
• • Participants under 21 years old will be excluded. Contraindications or limitations to contrast-enhanced MRI such as self-report of kidney disease, including kidney transplant or kidney surgery, eGFR less than 60, Metal fragments in eyes, brain, or spinal cord, Internal electrical devices such as cochlear implant, spinal cord stimulator, pacemaker, or defibrillator, pregnancy, allergic reaction to gadolinium in the past, claustrophobia, and cardiogenic shock or unstable condition that cannot tolerate the MRI scan will be excluded.