A Study to Assess the Safety and Efficacy of Centhaquine in Hypovolemic Shock Patients

Launched by PHARMAZZ, INC. · Jul 13, 2023

Keywords

ClinConnect Summary

This clinical trial is investigating a new drug called centhaquine citrate (LYFAQUIN™) to see if it is safe and effective for treating patients with hypovolemic shock, a serious condition that occurs when someone loses a lot of blood or fluid. The study is looking for adult patients who are 18 years or older and have low blood pressure (90 mmHg or less) and high blood lactate levels (above 2.0 mmol/L) when they arrive at the emergency room or intensive care unit. Patients who are unconscious for reasons other than hypovolemic shock, pregnant, or have certain other serious health issues will not be eligible to participate.

If someone qualifies for this trial, they will receive centhaquine in addition to the standard treatments they are already receiving for their shock. The researchers want to find out if this drug can help improve blood flow and overall recovery for patients experiencing this critical condition. The trial is currently recruiting participants, and those who take part will be contributing to important research that may help improve care for future patients with hypovolemic shock.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• • • Adult hypovolemic shock patients aged 18 years or older admitted to the emergency room or ICU with systolic blood pressure ≤ 90 mmHg at presentation and continue to receive standard shock treatment. Blood Lactate level indicative of hypovolemic shock (\>2.0 mmol/L).
• • Exclusion Criteria
• • Development of any other terminal illness not associated with hypovolemic shock during the study duration.
• • Patient with altered consciousness not due to hypovolemic shock and comatose patient. • Known pregnancy.
• • Cardiopulmonary resuscitation (CPR) before enrollment.
• • Presence of a do not resuscitate order.
• • Patient is participating in another interventional study.
• • Patients with systemic diseases which were already present before having trauma, such as sepsis, cancer, chronic renal failure, liver failure, decompensated heart failure, or AIDS.