Effects of 6-month of Treatment With TRPV1 and TRPA1 Agonists in Older Patients With OD

Launched by HOSPITAL DE MATARÓ · Jul 14, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two different treatments on older patients who have trouble swallowing, a condition known as oropharyngeal dysphagia (OD). The researchers want to see if using substances called TRPV1 (found in chili peppers) and TRPA1 (found in black pepper) can improve the swallowing process over six months. They will compare these treatments to a placebo (a treatment with no active ingredients) to find out if they help patients swallow more safely and effectively. The study will involve 150 participants aged 70 and older who have been diagnosed with OD.

To be eligible for the trial, participants must be at least 70 years old and show specific swallowing difficulties during testing. They should also be able to follow the study guidelines and provide written consent. Throughout the trial, participants will receive one of the treatments three times a day and will undergo various tests to measure how well they swallow and the impact on their overall health. This research aims to find new ways to help older adults regain their swallowing abilities, moving beyond just managing symptoms to actually improving function.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ≥70 years
• • With a positive Volume-Viscosity Swallow Test for oropharyngeal dysphagia
• • Penetration-aspiration scale \>1 in videofluoroscopy
• • Able to follow the protocol and to give written informed consent.
• Exclusion Criteria:
• • Life expectancy \< 3m or palliative care
• • Allergy to iodinated contrast or to the components of the treatment solutions
• • Cancer or active infection
• • Implanted electronic device
• • Epilepsy
• • Metal in the head
• • Participation in another clinical trial (previous month).