Neuropeptide Expression During the Ovarian Cycle and in Patients With PCOS

Launched by UNIVERSITY OF PERUGIA · Jul 20, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a condition called polycystic ovary syndrome (PCOS) by looking at certain substances in the blood and fluid around the ovaries, known as neuropeptides. Researchers want to understand how these neuropeptides change during different phases of the ovarian cycle in women with and without PCOS. They will compare three groups of women: those with regular menstrual cycles, non-PCOS women undergoing fertility treatment, and women with PCOS also undergoing fertility treatment. The goal is to see if there are differences in neuropeptide levels that could help us better understand PCOS and its effects on fertility.

To be eligible for this study, participants should be infertile women aged between 18 and 40, with a healthy body weight and specific hormone levels. Women with a confirmed diagnosis of PCOS according to established guidelines can also participate. Those who join the trial can expect to provide blood samples at different times during their menstrual cycle and during a fertility treatment procedure. This research is important because it aims to uncover insights that might improve treatment options for women struggling with PCOS and infertility.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • infertile women
• • BMI between 18 and 30 kg/m2,
• • basal FSH \< 10 IU/L,
• • number of antral follicles (2-10 m) per ovary \> 10,
• • regular uterine cavity assessed by hysterosalpinography, sonohysterography or hysteroscopy, and hematologic and biochemical parameters within normal limits will be included in the study, euthyroid status (with or without treatment)
• • In case of women with PCOS, it should be diagnosed according to the Rotterdam criteria (The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group (2004) Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome (PCOS).
• • No restrictions regarding the indication of infertility.
• Exclusion Criteria:
• • presence of ovaries inaccessible to oocyte pick-up,
• • presence of sactosalpinx, heterologous fertilization,
• • contraindication to pregnancy,
• • atypical genital discharge of unspecified cause,
• • uncontrolled dystothyroidism, presence of neoplasms,
• • severe alteration of liver or kidney function, taking medications that may interfere with the study.