Study on Brain Network Mechanism of Deep Brain Stimulation for Parkinson's Disease

Launched by TIANJIN HUANHU HOSPITAL · Jul 17, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how deep brain stimulation (DBS) can help people with Parkinson's Disease (PD), particularly looking at both the physical and emotional symptoms of the condition. DBS is a surgical procedure that can effectively reduce tremors, stiffness, and slow movements in PD patients. The researchers want to find out how to choose the best candidates for this treatment and how to evaluate their progress before and after the surgery. They will assess various aspects of the patients' health, including their thinking abilities, emotional well-being, and sleep quality, using specific tests designed for these areas.

To participate in this trial, candidates must be diagnosed with PD for at least five years and be under 75 years old. They should also show a good response to medication and have a clear indication for the DBS procedure. However, individuals with severe cognitive issues or serious mental health conditions will not be eligible. While the trial is not recruiting participants yet, those who do take part can expect thorough evaluations to help understand the benefits and outcomes of DBS for managing both motor and non-motor symptoms of Parkinson's Disease.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria:The clinical diagnosis of PD is consistent with the United Kingdom Parkinson's Disease Society Brain Bank criteria, with disease duration over 5 years, age under 75, acute levodopa motor response ≥30%, and indication for STN-DBS. -
• • Exclusion Criteria: patients with severe cognitive impairment, severe psychiatric disorders, acute levodopa motor response less than 30%, atypical parkinsonism, and contraindications to surgery -