Impact of Endometrial Compaction on Reproductive Outcomes After Cryotransfer of Euploid Embryos in a Natural Cycle

Launched by INSTITUTO BERNABEU · Jul 24, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how the thickness of the uterine lining, or endometrium, affects pregnancy outcomes after transferring healthy embryos in women undergoing fertility treatment. Specifically, it compares women who have a compacted endometrium at the time of embryo transfer to those whose endometrium is stable or thicker. The goal is to see if endometrial compaction impacts the chances of achieving an ongoing pregnancy with a euploid embryo, which means the embryo has the correct number of chromosomes.

To participate in this study, women aged 18 to 50 who are experiencing infertility may be eligible, provided they have a normal uterine cavity and are preparing for a single embryo transfer using a healthy embryo. However, women with certain uterine conditions, a history of recurrent pregnancy loss, or those who have difficulty measuring endometrial thickness may not qualify. Participants can expect to be part of a multi-center study, where their ongoing pregnancy rates will be tracked and compared based on their endometrial condition. This research could help us understand the best conditions for successful embryo implantation and improve fertility treatments.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Aged 18 to 50 years
• • Primary or secondary infertility
• • Normal uterine cavity
• • Endometrial preparation in a modified natural cycle for single embryo transfer
• • Embryo in blastocyst state from own oocyte or oocyte donation cycles, who had normal results on preimplantation genetic testing for aneuploidy (PGT-A) via trophectoderm biopsy.
• Exclusion Criteria:
• • Uterine or endometrial disease (multiple myomatosis \[\>3 fibroids of \> 3 cm\], adenomyosis, Asherman syndrome)
• • Difficulties in correctly measuring endometrial thickness due to a retroverted or tilted uterus
• • History of recurrent implantation failure (3 or more transferred blastocysts of good quality, from their own oocyte \[\<35 years\] or oocyte donation); recurrent early Pregnancy Loss (the loss of two or more pregnancies before 10 weeks of gestational age.
• • Suboptimal endometrial response (endometrium \< 6 mm on the day of ovulation triggering).