Influence of Short-Term Antibiotic Therapy on Exercise

Launched by RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY · Jul 17, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how a short course of antibiotics, specifically azithromycin, affects exercise performance in young, healthy adults. Researchers want to find out if taking this antibiotic for five days can change how well people can run on a treadmill. Previous studies in animals suggested that the gut microbiome, which consists of the bacteria in our digestive system, may play a role in muscle function and exercise, but similar research hasn’t been done in humans yet.

To participate in this study, you need to be between 18 and 40 years old, identify as male or female, and be able to run for 60 minutes on a treadmill without stopping. You should also have been active for at least 150 minutes each week over the past year. The study will have two groups: one will take azithromycin, and the other will take a placebo, which does not have any effect. Participants will be carefully monitored, and those with certain health conditions or who have recently used antibiotics or probiotics will not be eligible. This study is a great opportunity to contribute to important research that could help us understand the connection between our gut health and exercise.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18-40 years of age Must identify as male or female Able and willing to run for 60 minutes on a treadmill without stopping Completed a minimum of150 minutes per week of moderate-to-vigorous physical activity over the previous year. For participants who were assigned female at birth (i.e., born as biological females), they must currently use hormonal methods of contraception.
• Exclusion Criteria:
• • Use of either antibiotics or probiotics within the previous 12-weeksCurrently pregnant, trying to become pregnant, or breastfeeding Identification of a contraindication to exercise Previous diagnosis of any of the following: heart disease, peripheral vascular disease, high blood pressure, stroke, a heart murmur, sickle cell anemia, or a pulmonary(breathing) disorder. Previous hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide drug. History of cholestatic jaundice/hepatic dysfunction associated with prior use of azithromycin. Diagnosis of pneumonia within previous 6-months.