Neoadjuvant Toripalimab for Non-squamous NSCLC With EGFR Mutation

Launched by PEKING UNIVERSITY PEOPLE'S HOSPITAL · Jul 18, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at a new treatment approach for patients with a specific type of lung cancer called non-squamous non-small cell lung cancer (NSCLC) that has a mutation in the EGFR gene. The treatment being studied combines a medication called Toripalimab, which helps the immune system fight cancer, with chemotherapy before surgery to remove the tumor. The goal is to see how effective and safe this treatment is and to find out if certain tests can help predict how well patients will respond to this therapy.

To participate in this trial, patients must be between 18 and 70 years old and have a specific stage of lung cancer that can be surgically removed. They also need to have never received treatment for their cancer before and must have certain health conditions within acceptable limits, like good heart and lung function. Participants will be closely monitored throughout the study to assess how well the treatment works and to ensure their safety. It's important to note that this trial is not yet recruiting participants, so interested individuals will need to wait for it to start.

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Eligibility criteria

• Inclusion Criteria:
• • 1. Provision of signed informed consent by the patient or legally acceptable representative;
• • 2. Previously untreated, histologically confirmed resectable stage II-IIIA, IIIB(N2) (AJCC staging 8th edition) non-squamous non-small cell lung cancer;
• • 3. Adequate tissue samples for PD-L1 immunohistochemical testing and gene mutations test by RT-pCR or NGS, or consent for blood RT-PCR or NGS if tissue samples are insufficient;
• • 4. Harboring EGFR mutation (19del or L858R);
• • 5. Aged 18-70 years, regardless of gender;
• • 6. Eastern Cooperative Group (ECOG) Performance Status 0-1;
• • 7. Acceptable cardiac function with a left ventricular ejection fraction \>50%;
• • 8. Acceptable respiratory function (FEV1\>1.5L, DLCO\>50%) and ability to tolerate radical lung cancer surgery;
• • 9. Acceptable bone marrow haematopoiesis with leucocytes ≥ 4 x 10\^9/L, neutrophils ≥ 1.5 x 10\^9/L, haemoglobin ≥ 10g/dL and platelets ≥ 100 x 10\^9/L;
• • 10. Acceptable renal function with a glomerular filtration rate ≥ 60 mL/min;
• • 11. Acceptable liver function with total bilirubin ≤ 1.5 x ULN, AST ≤ 3 x ULN, and ALT ≤ 3 x ULN;
• • 12. Presence of measurable lesions as defined by RECIST 1.1 criteria;
• • 13. Women of childbearing potential must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 3 days prior to the start of study treatment, and agree to use effective contraception for the duration of study drug use and for 120 days after the last dose. Women of childbearing potential were defined as sexually mature females who 1) had not undergone hysterectomy or bilateral oophorectomy and 2) had not experienced spontaneous menopause for 12 consecutive months (amenorrhea after cancer treatment did not preclude fertility) (menstruation had occurred at any time during the previous 12 consecutive months).
• Exclusion Criteria:
• • 1. Pathological histologically confirmed small cell lung cancer, squamous epithelial cell carcinoma and other pathological subtypes cannot be enrolled;
• • 2. Patients with advanced or metastatic lung cancer, or unresectable lung cancer, or who have received previous systemic anti-tumour therapy such as immunotherapy, chemotherapy or targeted therapy cannot be enrolled;
• • 3. Patients with a history of active autoimmune disease or autoimmune disease that is likely to recur cannot be enrolled;
• • 4. Patients with active hepatitis B and C requiring relevant antiviral therapy need to have HBV-DNA \<500 IU/ml and have been on anti-HBV treatment for at least 14 days prior to study entry and continue treatment during the treatment period; HCV RNA-positive patients should be excluded;
• • 5. Patients who are allergic to chemotherapeutic agents such as carboplatin, paclitaxel, albumin paclitaxel, pemetrexed;
• • 6. Patients with a history of allergy to monoclonal antibody drugs;
• • 7. Patients who have previously received an allogeneic stem cell transplant or organ transplant；
• • 8. Patients with mental illness or any other illness that makes it impossible to comply with treatment；
• • 9. Patients who are unable or unwilling to sign the informed consent form；
• • 10. Patients with comorbidities or other conditions that, in the opinion of the investigator, may affect compliance with the protocol or make them unsuitable for participation in this study.