Short-term Fat Overfeeding on the Effects of Liver Metabolism

Launched by UNIVERSITY OF OXFORD · Jul 18, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how different types of dietary fats affect liver and heart health. Researchers want to understand if eating foods high in saturated fats (like butter and fatty meats) is linked to problems with the liver and heart compared to foods high in unsaturated fats (like olive oil and fish). Participants will be divided into two groups and will eat a high-fat diet that is either rich in saturated fats or unsaturated fats. The study will help determine how these diets affect things like liver fat and heart function after meals.

To join the study, participants must be between 18 and 65 years old and have a healthy body weight (not too low or too high). They should not have any serious health issues that would affect how their body processes fat. Participants can expect to follow a specific diet for a short period and will help researchers learn more about the effects of these fats on metabolism, which is how our bodies use food. It's important to note that certain people, such as smokers or those with specific medical conditions, may not qualify for the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • The participant is willing and able to give informed consent for participation in the study.
• • Male or Female, aged ≥18 or ≤65 years.
• • Body Mass Index ≥19 ≤35 kg/m2
• • No medical condition or relevant drug therapy that is known to affect liver or adipose tissue metabolism.
• • Weight stable for the previous 3 months
• Exclusion Criteria:
• • The participant is unwilling or unable to give informed consent for participation in the study. - Aged ≤18 or ≥65 years
• • Body Mass Index ≤19 or ≥35kg/m2
• • Blood haemoglobin \<135mg/dL for men and \<120mg/dL for women
• • Donated (or lost) ≥250 ml of blood in the previous two months.
• • On a weight loss diet or have decreased their body weight by \>5% in the previous 3 months.
• • Have increased their body weight by \>5% in the previous 3 months.
• • Any metabolic condition or relevant drug therapy
• • Current smoker
• • History of alcoholism or a greater than recommended alcohol intake (\>30 g of alcohol daily for men and \>20 g of alcohol daily for women)
• • Haemorrhagic disorders
• • Anticoagulant treatment
• • History of albumin allergy
• • Pregnant or nursing mothers
• • Women prescribed any contraceptive agent or device including oral contraceptives, hormone replacement therapy (HRT) or who have used these within the last 12 months History of severe claustrophobia
• • Presence of metallic implants, pacemakers, or are unwilling to remove any piercings
• • History of an eating disorder or any other psychological condition that may affect the participant's ability to adhere to study intervention/experimental diets.