Feasibility of Individualized, Model-guided Optimization of Proton Beam Treatment Planning in Patients With Low Grade Glioma

Launched by UNIVERSITY HOSPITAL HEIDELBERG · Jul 19, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring a new way to plan radiation treatment for patients with low-grade gliomas, which are slow-growing brain tumors. The study aims to see if a personalized approach, using models to guide the treatment, can improve outcomes for patients. Radiation therapy is an important part of treating these tumors, but doctors often debate the best time to start it to avoid potential long-term side effects. By participating in this trial, patients will contribute to understanding how to optimize radiation therapy for better results.

To be eligible for this trial, participants must be over 18 years old and have a confirmed diagnosis of low-grade glioma. They should require radiation treatment and be able to understand what the trial involves. However, individuals with prior brain radiation, certain medical conditions, or who are currently involved in another competing trial cannot participate. Those who join the study can expect to receive personalized treatment planning and will help researchers learn more about improving care for future patients with low-grade glioma.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age \> 18 years
• • histologically proven low-grade glioma
• • indication for definitive or adjuvant radiotherapy
• • ability to understand character and personal consequences of the clinical trial
• • written informed consent
• Exclusion Criteria:
• • previous cerebral irradiation
• • contraindication for contrast-enhanced MRI
• • neurofibromatosis
• • participation in another clinical trial with competing objectives