The China M-protein Screening Project in First-degree Relatives of Myeloma Patient - The CHAPERONE Study

Launched by SHANGHAI ZHONGSHAN HOSPITAL · Jul 20, 2023

Keywords

ClinConnect Summary

The CHAPERONE study is looking at how screening for a specific protein called M-protein can help identify early signs of a condition called monoclonal gammopathy in people who are closely related to patients with multiple myeloma, a type of blood cancer. This study aims to understand if screening can help find individuals who may be at risk of developing multiple myeloma in the future. By gathering information from these first-degree relatives, including parents, children, and siblings, researchers hope to learn more about what factors might lead to the progression of this disease.

To be eligible for the study, participants need to be at least 18 years old and have a close family member with a diagnosed case of multiple myeloma. It's important that participants understand the purpose of the study and agree to take part in the screening process. Those who are already diagnosed with related conditions like monoclonal gammopathy or multiple myeloma cannot participate. As a participant, you can expect to undergo screening tests and follow-up as part of the study, helping contribute valuable information that could improve understanding and treatment of this condition in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Male or female over the age of 18;
• • 2. First-degree relatives (including parents, children, and biological siblings) have multiple myeloma diagnosed by the International Myeloma Working Group (IMWG) Myeloma Diagnostic Criteria;
• • 3. Understand the purpose and procedure of this trial and voluntarily participate in this screening study;
• • 4. Participants should be willing and able to follow the study follow-up plan and other protocol requirements.
• Exclusion Criteria:
• • Patients with a known diagnosis of plasma cell diseases, such as MGUS, smoldering myeloma (SMM), or multiple myeloma