The Effects of Dietary Erythritol on Platelet Reactivity and Vascular Inflammation

Launched by UNIVERSITY OF CALIFORNIA, DAVIS · Jul 21, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how a sweetener called erythritol affects the way our blood cells, known as platelets, behave and how it impacts inflammation in our blood vessels. Participants will drink beverages sweetened with either erythritol or another sweetener called aspartame for two weeks at a time, alternating between the two in a randomized order. The goal is to see if erythritol has any different effects compared to aspartame.

To participate in the trial, you need to be between the ages of 65 and 74 and have a body mass index (BMI) of 27 or higher. However, people with a history of certain medical conditions, such as blood clots or heart problems, or who are currently pregnant or using specific medications, won't be eligible. If you join the study, you can expect to follow a specific diet and avoid certain medications during the trial period. It's a great opportunity to help researchers learn more about how what we eat can affect our health!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • BMI ≥ 27 kg/m2
• Exclusion Criteria:
• • • History of blood clot, transient ischemic attack (TIA), stroke, angina, heart attack, or peripheral vascular disease, or current cancer diagnosis.
• • Pregnant or lactating women
• • Current, prior (within 12 months), or anticipated use of medications for treatment of hyperlipidemia, high blood pressure or diabetes, or any medication that in the opinion of the investigators will confound results.
• • Unwilling to forego the use of anti-inflammatory medication during study.
• • Unwilling to forego the use of marijuana during the study.
• • Use of tobacco.
• • Strenuous exerciser (\>4 hours/week at a level more vigorous than walking).
• • Surgery or medication for weight loss.
• • Diet exclusions: Food allergies or dietary restrictions that may undermine compliance to dietary protocol, routine ingestion of more than 2 sugar-sweetened beverages or 2 alcoholic beverage/day. Unwillingness to consume artificial or noncaloric sweeteners. Habitual consumption (\>10 gram/day) of beverage or foods that contain erythritol. Recent or current weight loss diet.