Evaluation the Efficacy Between Botox Injection and Combination Pharmacotherapy in Patients With Detrusor Overactivity
Launched by MACKAY MEMORIAL HOSPITAL · Jul 29, 2023
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying the effects of a Botox injection in the bladder compared to a combination of two medications, Mirabegron and Solifenacin, for women who have a condition called detrusor overactivity. This condition means that the bladder muscles contract involuntarily, which can lead to a frequent and urgent need to urinate. The trial is looking for women who have not had success with standard single treatments for this issue.
To participate in this study, applicants must have experienced involuntary bladder contractions and should not have had success with either of the medications used alone. However, those who retain urine after urination will not be eligible to join. If you qualify and agree to participate, you will receive either the Botox injection or the combination of medications to see which treatment works best for you. The trial is currently recruiting participants, and it aims to find more effective treatment options for women suffering from this condition.
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • Patients with detrusor overactivity which defined as a urodynamic observation characterized by involuntary detrusor contractions during the filling phase. Those who were refractory to monotherapy with either anti-muscarinics or β3-adrenoceptor agonists were enrolled for prospective study
- Exclusion Criteria:
- • Postvoid urine retention before treatment
About Mackay Memorial Hospital
Mackay Memorial Hospital is a leading healthcare institution dedicated to advancing medical science through innovative clinical research. With a commitment to patient-centered care, the hospital actively sponsors and conducts clinical trials across various therapeutic areas, aiming to develop new treatment options and improve health outcomes. Boasting a team of experienced researchers and healthcare professionals, Mackay Memorial Hospital adheres to rigorous ethical standards and regulatory guidelines, ensuring the safety and well-being of participants while contributing to the global body of medical knowledge. Its collaborative approach fosters partnerships with academic institutions and industry leaders, positioning it as a key player in the advancement of healthcare solutions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Taipei, , Taiwan
Patients applied
Trial Officials
Hui-Hsuan Lau, MD
Principal Investigator
Mackay Memorial Hospital
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported