Comparing Ciprofol and Propofol for Sedation in Hypotensive ICU Patients: a Single Center Prospective Cohort Study

Launched by NANFANG HOSPITAL, SOUTHERN MEDICAL UNIVERSITY · Jul 24, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the safety and effectiveness of two sedation medications, Ciprofol and Propofol, for patients in the Intensive Care Unit (ICU) who have low blood pressure and need additional medications to support their blood pressure. The trial aims to compare how well these two medications work in helping patients feel comfortable and safe while receiving life-saving treatments. It plans to include a total of 456 patients over two years, with some receiving Ciprofol and others receiving Propofol, based on their doctor’s recommendation.

To be eligible for this study, participants must be at least 18 years old and need treatment with medications to help maintain a stable blood pressure. They should also require sedation for their comfort and safety. However, pregnant women, individuals with certain severe medical conditions, or those with allergies to the study medications may not participate. If you or a loved one is considering joining this trial, you can expect to have your medical information closely monitored, and the research team will ensure that you are well-informed throughout the process.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18;
• • It needs to be treated with vasopressors to maintain mean arterial pressure ≥65 mmHg;
• • Sedative medication required for comfort, safety, and to facilitate life support measures;
• • Obtain the informed consent of the human subjects or their legal representatives.
• Exclusion Criteria:
• • Pregnant patient;
• • Patients with proven acute severe intracranial or spinal neurological disease due to vascular, intracranial dilatation, or injury;
• • History of allergy to cyclopofol, propofol, eggs, or soy products;
• • History of long-term use of benzodiazepines or opioids;
• • Sedative drugs other than propofol or cyclopofol were used at enrollment, or propofol and cyclopofol were used alternately within 24 hours;
• • The researchers judged that they are not suitable to participate in this study.