Perioperative Oral Decontamination and ImmunoNuTrition (POINT) in Elderly

Launched by PEKING UNION MEDICAL COLLEGE HOSPITAL · Jul 31, 2023

Keywords

ClinConnect Summary

This clinical trial, called POINT, is studying how certain treatments can help prevent lung problems after surgery in older adults aged 65 and above. Specifically, it looks at the effects of an immunonutrition supplement, which is a special nutritional drink designed to boost the immune system, and a mouth rinse containing chlorhexidine, which helps reduce germs in the mouth. Participants will be randomly assigned to receive either these treatments or standard care. The trial aims to see if these interventions can lower the risk of complications related to breathing after major non-cardiac surgeries.

To be eligible for this trial, participants must be at least 65 years old and scheduled for major surgery that requires general anesthesia. They should also be assessed to have a higher risk of breathing complications based on a specific scoring system. Those who are not eligible include individuals having emergency surgeries, those with pre-existing lung infections, or certain health conditions that could interfere with the treatments. If you join the trial, you can expect close monitoring during your surgery and recovery, and you'll be contributing to important research that could benefit many elderly patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. age≥65 years;
• • 2. undergoing major non-cardiac surgery;
• • 3. scheduled for general anesthesia and endotracheal intubation;
• • 4. American Society of Anesthesiologists (ASA) physical status classification I-IV;
• • 5. with intermediate to high risk of respiratory complications assessed by Assess Respiratory Risk in Surgical Patients in Catalonia (ARISCAT) score;
• • 6. informed consent obtained.
• Exclusion Criteria:
• • 1. emergency surgery;
• • 2. preoperative pneumonia;
• • 3. allergic to chlorhexidine;
• • 4. severe hepatic/renal dysfunction, incapable of oral feeding, with autoimmune diseases, taking immunosuppressant or immunoregulation medications, or with other contraindication to immunonutrition supplementation;
• • 5. expected intervention of immunonutrition\<3 days.