ClinConnect ClinConnect Logo
Search / Trial NCT05972876

Graft Maturity After Blood Flow Restriction Training in ACL Reconstruction

Launched by ZUYDERLAND MEDISCH CENTRUM · Jul 25, 2023

Trial Information

Current as of July 24, 2025

Recruiting

Keywords

Blood Flow Restriction Therapy

ClinConnect Summary

This clinical trial is studying the effects of a new type of exercise called low-load blood flow restriction training (LL-BFRT) on patients who have undergone surgery to reconstruct their anterior cruciate ligament (ACL). The aim is to see if this gentler training method helps the ACL graft mature better compared to traditional heavy-load resistance training (HLRT), which may not be as beneficial for healing. Researchers will measure the maturity of the graft using MRI scans at three and nine months after surgery, along with other factors like knee stability, muscle strength, and overall patient satisfaction.

To participate in this trial, individuals aged 18 to 64 who are scheduled for a specific type of ACL reconstruction (bone-patellar tendon-bone grafting) at Zuyderland Medical Center may be eligible. However, certain health conditions, like severe hypertension or blood clotting disorders, may prevent someone from joining. Participants will engage in biweekly strength training sessions starting two weeks after their surgery for a total of 12 weeks. This study aims to provide valuable insights into the best rehabilitation methods to help patients recover safely and effectively after ACL surgery.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Patients (18-64 years) who will undergo primary BPTB reconstruction at Zuyderland Medical Center and rehabilitation at Knie-Heup centrum Plus.
  • Exclusion Criteria:
  • venous thromboembolism, sickle cell anemia, severe hypertension, contra-indication for accelerated rehabilitation, contra-indication for MRI scan or not willing/able to participate.

About Zuyderland Medisch Centrum

Zuyderland Medisch Centrum is a leading healthcare institution in the Netherlands, renowned for its commitment to advancing medical research and improving patient care. With a multidisciplinary approach, the center integrates innovative clinical trials into its healthcare services, fostering collaboration among specialists to explore new therapies and treatment modalities. Zuyderland Medisch Centrum prioritizes patient safety and ethical standards in all research endeavors, aiming to contribute valuable insights to the medical community and enhance health outcomes for diverse populations. Through its state-of-the-art facilities and a dedicated team of researchers and clinicians, the center strives to remain at the forefront of medical advancements.

Locations

Sittard, Limburg, Netherlands

Patients applied

0 patients applied

Trial Officials

Jasper Most

Principal Investigator

Zuyderland Medisch Centrum

Baris Koc, MD, PhDc

Study Director

Zuyderland Medisch Centrum

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported