Blood Lipid Responses to Diet

Launched by UNIVERSITY OF OXFORD · Jul 31, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how different amounts of carbohydrates and fats in our diets affect blood lipid levels (fats in the blood) and liver function in healthy adults. The researchers want to understand the best dietary balance to help lower the risk of heart disease and other metabolic conditions. They will also look at how a person's genes may influence how their body responds to these dietary changes.

To participate in this study, individuals must be between 18 and 65 years old, have a stable weight for the last three months, and have a body mass index (BMI) within a specific range. Participants should not have any medical conditions or take medications that could affect metabolism. Those who join can expect to follow a specific diet and undergo testing to measure their blood lipid levels and liver health. It's important to note that people with certain health issues, significant weight changes, or other specific criteria will not be eligible for this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participant is willing and able to give informed consent for participation in the study.
• • Male or Female, aged ≥18 to ≤65 years
• • Body mass index (BMI) ≥19 to ≤35 kg/m2
• • No medical condition or relevant drug therapy that is known to affect the liver, adipose tissue, or cardiac metabolism.
• • Weight stable for the previous 3 months
• Exclusion Criteria:
• • Aged \<18 or \>65 years
• • BMI \<19 or \>35 kg/m2
• • A blood haemoglobin \<135 mg/dL for men and \<120 mg/dL for women
• • Donated (or lost) ≥250 mL of blood in the previous two months
• • On a weight loss diet or decreased their body weight by \>5% in the previous 3 months
• • Currently adhering to or have consumed in the previous 3 months a diet with a notably altered macro-nutrient content (e.g. high-fat - low-carbohydrate diet)
• • Have increased their body weight by \>5% in the previous 3 months
• • Any metabolic condition or relevant drug therapy
• • Current smoker
• • History of alcoholism or a greater than recommended alcohol intake (\>30 g of alcohol daily for men and \>20 g of alcohol daily for women)
• • History of albumin allergy.
• • Pregnant or nursing mothers
• • History of severe claustrophobia