Effect of Fasting on Hypoglycemic Counterregulation in Type 1 Diabetes

Launched by UNIVERSITY OF CINCINNATI · Jul 25, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how fasting affects the body’s response to low blood sugar (hypoglycemia) in people with type 1 diabetes. Researchers want to understand if fasting changes how the body reacts to insulin-induced hypoglycemia, which is when blood sugar levels drop too low due to insulin treatment. This is important because people with type 1 diabetes often struggle with managing low blood sugar, and understanding these responses could help improve their care.

To participate in the study, individuals must be between the ages of 18 and 75, have a diagnosis of type 1 diabetes, and have a body mass index (BMI) of 30 or less. Pregnant women, smokers, and those taking certain medications or with specific health conditions will not be eligible to join. If selected, participants can expect to undergo tests that measure their body’s response to low blood sugar after fasting. This trial is currently recruiting, and it aims to gather valuable information that could lead to better management strategies for people living with type 1 diabetes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • males and females of any race or ethnicity
• • non-obese (BMI \< or = to 30)
• • have a diagnosis of type 1 diabetes
• • C-peptide negative
• Exclusion Criteria:
• • pregnant women
• • cigarette smoking
• • Taking inflammation-targeting steroids (e.g., prednisone).
• • Taking medications targeting adrenergic signaling (e.g., beta-blockers, bronchodilators).
• • Hematocrit less than 33%.
• • Presence of HIV or hepatitis (due to their deleterious effects on the liver).
• • The presence of cardiovascular or peripheral vascular disease.
• • The presence of neuropathy, retinopathy or nephropathy.
• • A detection of the presence of any other disease or condition by one of the study doctors, that would be expected to confound the responses to insulin-induced hypoglycemia or make participation in the study dangerous to the individual.