Transplantation of Bone Marrow Mesenchymal Stromal Cells for Periodontal Regeneration

Launched by INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTIFICAS · Jul 27, 2023

Keywords

ClinConnect Summary

The clinical protocol is designed to evaluate the bone regeneration capacity of allogeneic MSCs for the treatment of patients with chronic or aggressive periodontal disease. Patients with either a 2- or 3-wall intrabony defects are included in this study. A bioengineering construct, constituted by allogeneic MSCs and a collagen scaffold, is incorporated into platelet rich plasma (PRP) clot, which is implanted at the bone defect site. Follow up of treated tooth are assessed by clinical evaluation, intraoral radiography and cone-beam CT.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Medical healthy
• • Minimum age of 18 years old
• • Diagnosis of chronic or aggressive periodontitis
• • Vertical intrabony defects of three or two walls
• • PPD \>= 5 mm
• • Radiographic evidence of alveolar bone loss of at least 3 mm
• • Minimim 20 teeth presents in mouth.
• • Informed consent of the patient
• Exclusion Criteria:
• • Smoking
• • Pregnancy or lactating
• • Receiving immunosuppressive drugs, anticoagulants, antibiotics or analgesic drugs
• • Diabetics