Brain Slice Explants to Predict Drug Response in Brain Tumors

Launched by UNC LINEBERGER COMPREHENSIVE CANCER CENTER · Jul 28, 2023

Keywords

ClinConnect Summary

This clinical trial, titled "Brain Slice Explants to Predict Drug Response in Brain Tumors," is studying how to better understand how different drugs might work for patients with central nervous system (CNS) tumors. The researchers want to find out if they can take small samples of tumor tissue from patients who are having surgery and test them in a lab to see how effective various treatments could be. This is important because CNS tumors can be very different from one person to another, and currently, there isn’t a reliable way to predict which treatment will work best for each individual.

To be eligible for this study, participants must have a CNS tumor that is scheduled to be surgically removed, and they need to provide consent to take part in the study. This applies to both adults and children. Participants can expect to have their tumor tissue tested in a lab setting to help researchers learn more about how different drugs might respond to their specific tumor characteristics. The study is currently recruiting participants, and it aims to gather valuable information that could lead to more personalized and effective treatment options for people with brain tumors.

Gender

ALL

Eligibility criteria

• • In order to participate in this study a subject must meet all of the eligibility criteria outlined below.
• Inclusion Criteria:
• • 1. Written informed consent obtained to participate in the study and HIPAA authorization for the release of personal health information or written assent and parental consent for pediatric subjects or surrogate consent provided by the subject's legally authorized guardians.
• • 2. A diagnosis of a tumor residing in the central nervous system with surgery plan to have surgical resection.
• • 3. The subject is willing and able to comply with study procedures based on the judgment of the investigator or protocol designer.
• Exclusion Criteria:
• 1. All subjects must not meet any of the following exclusion criteria prior to enrollment to participate in this study:
• • Any serious medical or psychiatric disorder that would interfere with the subject's ability to give informed consent.
• • 2. Incarcerated individuals.