Feasibility Study of Sentinel Navigation Surgery in Early Gastric Cancer Using Fluorescence (SENORITA4)

Launched by NATIONAL CANCER CENTER, KOREA · Jul 31, 2023

Keywords

ClinConnect Summary

The SENORITA4 trial is studying a new way to perform surgery for early gastric cancer, which is cancer that starts in the stomach and has not spread. In this study, researchers want to see if using a special type of dye called fluorescence—rather than a radioactive substance—can help doctors find sentinel lymph nodes during surgery. These are the first lymph nodes that cancer might spread to, and identifying them is important for treatment. The goal is to see if this method can be done safely and effectively while also preserving more of the stomach, which could help improve patients' quality of life.

To be eligible for this study, participants must be between 20 and 80 years old and have a specific type of stomach cancer that is less than 3 centimeters in size. They should also be in good health with minimal limitations in daily activities. Patients who are pregnant, have certain health issues, or have had previous surgeries that might complicate the procedure may not be able to participate. Those who join the trial will receive laparoscopic surgery, which is a minimally invasive approach, meaning they will have smaller cuts and potentially quicker recovery times. Overall, this trial is still in the planning stages and has not yet started recruiting participants.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • single lesion of adenocarcinoma in preoperative endoscopic biopsy clinical stage T1N0 in the preoperative evaluation of endoscopy and computed tomography
• • tumor size: less than 3cm
• • location: 2cm far from the pylorus or cardia
• • aged 20 to 80
• • ECOG 0 or 1
• • patient who signed the agreement
• • patient who is suspected to underwent laparoscopic or robotic gastrectomy
• Exclusion Criteria:
• • indication of endoscopic submucosal resection
• • inoperable due to poor cardiac, and pulmonary function
• • pregnant
• • having allergic reaction, previous upper abdominal surgery except laparoscopic cholecystectomy, previous radiation therapy to upper abdomen
• • diagnosed as malignancy within 5 years except carcinoma in situ of cervix cancer and thyroid cancer