Remimazolam for Cataract Surgery

Launched by UNIVERSITY OF CALIFORNIA, LOS ANGELES · Aug 4, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two medications, Midazolam and Remimazolam, on memory and thinking skills after cataract surgery. The main goal is to see if either medication causes changes in cognitive function, which refers to how well a person can think and remember, after surgery. Participants will be adults aged 65 and older who are undergoing their first eye cataract surgery at UCLA. They will undergo a simple memory test before surgery and again after surgery to check for any changes.

If you join this study, you’ll be randomly assigned to receive either Midazolam or Remimazolam during your surgery. You’ll complete a memory assessment at two different times: right after you wake up from anesthesia and the day after your surgery. Additionally, you will fill out a satisfaction survey to share your experience with the care you received. It’s important to note that certain individuals, such as those with significant hearing or vision impairments or those who do not wish to receive benzodiazepine medication, may not be eligible to participate in this trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Adult patients age \> 65 years undergoing first eye cataract surgery under local topical anesthesia at the University of California, Los Angeles (UCLA).
• • 2. Both male and female patients
• • 3. American Society of Anesthesiologists Class 2, 3, and 4.
• Exclusion Criteria:
• • 1. Patients who are unable to consent for the study
• • 2. Patients who are unable to cooperate with the cognitive assessment such as patients with significant visual, auditory, language or other impairment.
• • 3. Patients who are unable to understand simple English commands.
• • 4. Patients who do not wish to have benzodiazepine medication during surgery
• • 5. Patients with a history of severe hypersensitivity reaction to dextran 40 or products containing dextran 40.
• • 6. Patients with chronic pain on opiates.
• • 7. Patients with a history of drug, alcohol abuse/dependence.
• • 8. Patients with BMI \> 40.
• • 9. Patients with obstructive sleep apnea (moderate to severe).