Genicular and Anterior Femoral Cutaneous Nerve Blocks for Total Knee Arthroplasty

Launched by HOSPITAL FOR SPECIAL SURGERY, NEW YORK · Jul 31, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two specific nerve blocks, called the genicular nerve block and the anterior femoral cutaneous nerve block, on pain management and opioid use in patients undergoing total knee replacement surgery. The main questions the researchers are looking to answer include whether these nerve blocks can help reduce the amount of opioid medication patients need in the first 24 hours after surgery, lower pain scores, and allow for quicker recovery in the post-anesthesia care unit.

To be eligible for this study, participants should be between the ages of 18 and 80 and scheduled for a single knee surgery. They should not have a history of chronic pain or opioid use, nor any conditions that would make the nerve blocks unsafe. If you choose to participate, you will be randomly assigned to either receive the nerve blocks along with standard care or to receive standard care alone. Overall, this trial aims to find ways to improve pain relief and recovery for knee surgery patients while potentially reducing reliance on opioids.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • patients age 18-80
• • patients undergoing ambulatory unilateral total knee arthroplasty, including 23 hour stay cohort
• • ASA I-III
• • BMI \< 35
• Exclusion Criteria:
• • history of chronic pain syndromes
• • chronic opioid use (daily morphine milligram equivalents \> 30 mg for at least 3 months)
• • contraindication to peripheral nerve blocks
• • contraindication to neuraxial anesthesia
• • history of peripheral neuropathy or pre-existing neurological deficits
• • Psychiatrics or cognitive disorder that prohibit patient from following study protocol
• • allergy to local anesthetic or study medications
• • multiligament surgery
• • history of substance abuse
• • infection at the site of injection
• • chronic kidney disease
• • currently taking anticonvulsants