The Effectiveness of Vitamin D Supplementation in Patients With End-stage Knee Osteoarthritis

Launched by CHINESE UNIVERSITY OF HONG KONG · Jul 31, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effects of vitamin D supplements on patients with end-stage knee osteoarthritis (OA), a painful condition that affects movement and often leads to disability in older adults. The researchers want to see if taking vitamin D can improve muscle strength, physical function, and pain levels in patients who are waiting for knee replacement surgery. To be eligible for the study, participants must be over 50 years old, on the waiting list for a total knee replacement at Prince of Wales Hospital, and have low levels of vitamin D in their blood.

Participants in the trial will receive either vitamin D supplements or a placebo (a non-active pill) for a period of time, and their muscle strength and overall health will be assessed at several points over the course of a year. The study aims to discover if vitamin D can help ease symptoms and improve quality of life for those suffering from knee OA. It’s important to note that individuals with certain conditions, like recent hip or knee surgery, malnutrition, or severe kidney problems, will not be eligible to participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male and female patients aged over 50 with end-stage knee OA
• • Patient are on the waiting list for TKR at Prince of Wales Hospital
• • Walk unaided for 6 meters
• • Able to comply with the assessments and has given oral and written consent
• • Patients with vitamin D insufficiency and deficiency at the baseline measurement (25(OH)D \<30 ng/mL)
• Exclusion Criteria:
• • Patients with connective tissue disorders or myositis condition
• • History of any Hip \& Knee surgery
• • Patients with malnutrition were assessed by Mini-Nutritional assessment.
• • Patients with acute immobility (i.e., post-hip fracture or post-acute hospital admission)
• • Patient scheduled for TKR within six months
• • Patients already taking vitamin D supplements
• • Patients with a known contraindication to vitamin D treatment (such as allergy)
• • Patients who have renal impairment with glomerular filtration rate (eGFR) \< 30 ml/minute