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Search / Trial NCT05984277

A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer.

Launched by ASTRAZENECA · Aug 2, 2023

Trial Information

Current as of October 22, 2025

Recruiting

Keywords

Metastatic Non Small Cell Lung Cancer Non Squamous Tumors Squamous Tumors Pd L1

ClinConnect Summary

The eVOLVE-Lung02 clinical trial is studying a new treatment for patients with metastatic non-small cell lung cancer (NSCLC), which is a type of lung cancer that has spread to other parts of the body. This trial is comparing two treatment options: one that includes a drug called volrustomig combined with chemotherapy, and another that combines a drug called pembrolizumab with chemotherapy. The goal is to see which combination works better and is safer for patients with a specific type of NSCLC who have a certain level of a protein called PD-L1.

To participate in this trial, patients should be between the ages of 65 and 74 and have a confirmed diagnosis of stage IV non-small cell lung cancer that cannot be treated with surgery or radiation. Participants should not have specific genetic changes in their tumors that would make them eligible for other targeted treatments. Throughout the trial, participants will receive treatment and have regular check-ups to monitor their health and how well the treatments are working. If you or a loved one are considering joining this study, it's important to discuss it with your healthcare team to see if it’s a good fit.

Gender

ALL

Eligibility criteria

  • Key Inclusion Criteria:
  • Histologically or cytologically documented squamous or non-squamous NSCLC.
  • Stage IV NSCLC (according to Version 8 of the IASLC Staging Manual in Thoracic Oncology 2016), not amenable to curative surgery or radiation.
  • Absence of sensitizing EGFR mutations and ALK and ROS1 rearrangements.
  • Absence of documented tumor genomic alteration results from tests conducted as part of standard local practice in any other actionable driver oncogenes for which there are locally approved targeted first-line therapies.
  • Key Exclusion Criteria:
  • Mixed small-cell lung cancer and NSCLC histology or sarcomatoid variant. Rare subtypes are excluded.
  • Spinal cord compression.
  • Symptomatic brain metastases. Brain metastases may be treated or untreated, but participants must be asymptomatic and off steroids for at least 14 days prior to start of study intervention. A minimum of 2 weeks must have elapsed between the end of brain radiotherapy and study enrollment.
  • * History of another primary malignancy except for:
  • 1. Malignancy treated with curative intent with no known active disease ≥ 2 years before the first dose of study intervention and of low potential risk for recurrence.
  • 2. Adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease.
  • 3. Adequately treated carcinoma in situ without evidence of disease.
  • As judged by the investigator, any condition that would interfere with evaluation of the study intervention or interpretation of participant safety or study results.

About Astrazeneca

AstraZeneca is a global biopharmaceutical company dedicated to the discovery, development, and commercialization of innovative medicines across various therapeutic areas, including oncology, cardiovascular, respiratory, and autoimmune diseases. With a strong commitment to scientific research and patient-centric solutions, AstraZeneca leverages cutting-edge technology and a robust pipeline to address unmet medical needs. The company collaborates with healthcare professionals, academic institutions, and other organizations to advance clinical trials and deliver transformative therapies, aiming to improve health outcomes and enhance the quality of life for patients worldwide.

Locations

Cleveland, Ohio, United States

Baltimore, Maryland, United States

Fairfax, Virginia, United States

Nashville, Tennessee, United States

Indianapolis, Indiana, United States

Hot Springs, Arkansas, United States

Towson, Maryland, United States

Detroit, Michigan, United States

Gent, Belgium

Barretos, Brazil

Praha 2, Czechia

Székesfehérvár, Hungary

Trnava, Slovakia

Madrid, Spain

Long Beach, California, United States

Tacoma, Washington, United States

Dresden, Germany

Boston, Massachusetts, United States

Columbus, Ohio, United States

Tuebingen, Germany

Gainesville, Florida, United States

Portland, Oregon, United States

Albany, New York, United States

Calgary, Alberta, Canada

Edmonton, Alberta, Canada

Winnipeg, Manitoba, Canada

Toronto, Ontario, Canada

Caen, France

Padova, Italy

Roma, Italy

Antwerpen, Belgium

Budapest, Hungary

Milano, Italy

Barcelona, Spain

Barcelona, Spain

Linz, Austria

Wels, Austria

Heidelberg, Australia

Bordeaux, France

Lille, France

Bari, Italy

Nieuwegein, Netherlands

Lublin, Poland

Torun, Poland

Des Moines, Iowa, United States

Baltimore, Maryland, United States

Pittsburgh, Pennsylvania, United States

Oshawa, Ontario, Canada

Debrecen, Hungary

Levis, Quebec, Canada

Denver, Colorado, United States

Saint Petersburg, Florida, United States

Marrero, Louisiana, United States

Annapolis, Maryland, United States

Grand Island, Nebraska, United States

Lincoln, Nebraska, United States

Memphis, Tennessee, United States

Aalst, Belgium

Pavia, Italy

Omaha, Nebraska, United States

Tallahassee, Florida, United States

Newark, Delaware, United States

Lexington, Kentucky, United States

Nashville, Tennessee, United States

Quimper Cedex, France

Freiburg, Germany

Halle, Germany

Nürnberg, Germany

Mexico City, Mexico

Paris Cedex 5, France

Houston, Texas, United States

Columbus, Ohio, United States

Halifax, Nova Scotia, Canada

La Plata, Argentina

Sao Paulo, Brazil

Deszk, Hungary

Johannesburg, South Africa

Taipei, Taiwan

Taipei, Taiwan

Taipei, Taiwan

Heidelberg, Germany

Budapest, Hungary

Budapest, Hungary

Kecskemét, Hungary

Törökbálint, Hungary

São Paulo, Brazil

Málaga, Spain

West Palm Beach, Florida, United States

South Brisbane, Australia

Amsterdam, Netherlands

Poznan, Poland

Fitzroy, Australia

Lévis, Quebec, Canada

Prague, Czechia

Bratislava, Slovakia

Fort Myers, Florida, United States

Hattiesburg, Mississippi, United States

Dayton, Ohio, United States

Irving, Texas, United States

Beijing, China

Beijing, China

Beijing, China

Chongqing, China

Shanghai, China

Ravenna, Italy

Olsztyn, Poland

Bloemfontein, South Africa

Tainan, Taiwan

Roma, Italy

Kosice, Slovakia

Lodz, Poland

Birmingham, United Kingdom

Prescott, Arizona, United States

Fort Wayne, Indiana, United States

Tianjin, China

Taoyuan, Taiwan

St. Petersburg, Florida, United States

Des Moines, Iowa, United States

Baton Rouge, Louisiana, United States

East Syracuse, New York, United States

New Delhi, India

Nagoya Shi, Japan

Suwon Si, Korea, Republic Of

Bangkok, Thailand

Barrie, Ontario, Canada

Koblenz, Germany

Pretoria, South Africa

Truro, United Kingdom

Matsuyama Shi, Japan

Clayton, Australia

Curitiba, Brazil

Guangzhou, China

Nanning, China

Pécs, Hungary

Szekszárd, Hungary

Lublin, Poland

Parktown, South Africa

Soweto, South Africa

Kaohsiung, Taiwan

London, United Kingdom

Bayonne, France

Kashiwa, Japan

Koto Ku, Japan

Essen, Germany

Tübingen, Germany

George, South Africa

Bonn, Germany

Fukuoka, Japan

London, United Kingdom

Reims, France

Montpellier, France

Marseille, France

Albuquerque, New Mexico, United States

Ludwigsburg, Germany

Palo Alto, California, United States

Changchun, China

Shanghai, China

Taiyuan, China

Wuhan, China

Parma, Italy

Ghent, Belgium

Monterrey, Mexico

Seoul, Korea, Republic Of

Gauting, Germany

London, United Kingdom

Lone Tree, Colorado, United States

Blackpool, United Kingdom

Strasbourg, France

Milan, Italy

Toruń, Poland

Nanchang, China

Gyöngyös, Hungary

Cheongju Si, Korea, Republic Of

Groningen, Netherlands

Belleville, New Jersey, United States

Rosario, Argentina

Chicoutimi, Canada

Changsha, China

Limoges, France

Alicante, Spain

Porto Alegre, Brazil

Colchester, United Kingdom

Warsaw, Poland

Okayama Shi, Japan

Strasbourg Cedex, France

Gyöngyös Mátraháza, Hungary

Bergamo, Italy

Nanjing, China

Shanghai, China

Bengbu, China

Hangzhou, China

Wuhan, China

Yangzhou, China

Zhengzhou, China

Kawasaki Shi, Japan

Yokohama Shi, Japan

Győr, Hungary

Osaka Shi, Japan

Porto Alegre, Brazil

Daegu, Korea, Republic Of

Hsinchu, Taiwan

New Taipei City, Taiwan

Antalya, Turkey

Incheon, Korea, Republic Of

Bonn, Germany

Freiburg Im Breisgau, Germany

Tainan City, Taiwan

Tainan City, Taiwan

Catanzaro, Italy

Banska Bystrica, Slovakia

Sendai Shi, Japan

Ube Shi, Japan

Muang, Thailand

Olomouc, Czechia

Praha, Czechia

Tilburg, Netherlands

Springdale, Arkansas, United States

Sagamihara Shi, Japan

Suwon, Korea, Republic Of

Taipei City, Taiwan

Rzeszów, Poland

Amanzimtoti, South Africa

Poznań, Poland

Rosario, Argentina

Warszawa, Poland

New Taipei, Taiwan

Velbert, Germany

Rondebosch, South Africa

Bilbao (Vizcaya), Spain

Toulon Naval, France

Fukuoka Shi, Japan

Osakasayama Shi, Japan

Ankara, Turkey

Praha, Czechia

Nagoya, Japan

Okayama, Japan

Osaka, Japan

Orlando, Florida, United States

Taipei, Taiwan

Immenhausen, Germany

Lanzhou, China

Linhai, China

Bratislava, Slovakia

Florianópolis, Brazil

Wuhan, China

Istanbul, Turkey

Fresh Meadows, New York, United States

Córdoba, Argentina

Fortaleza, Brazil

Louisville, Kentucky, United States

Sydney, Australia

Pamukkale, Turkey

Hefei, China

Ostrava Vitkovice, Czechia

Hangzhou, China

Xi'an, China

Tomaszów Mazowiecki, Poland

Songkhla, Thailand

Chengdu, China

Lampang, Thailand

Diyarbakir, Turkey

Suresnes, France

Hefei, China

Yunlin, Taiwan

Hyderabad, India

Georgsmarienhütte, Germany

Mysuru, India

Radom, Poland

Fuzhou, China

Gütersloh, Germany

Georgsmarienhuette, Germany

Natal, Brazil

Guadalajara, Mexico

Bunkyo Ku, Japan

Nagpur, India

Košice, Slovakia

Johannesburg, South Africa

Kaohsiung City, Taiwan

Kolkata, India

Mexico City, Mexico

Culiacan, Mexico

Caba, Argentina

Westbury, New York, United States

Lévis, Quebec, Canada

Palma, Spain

Shenzhen, China

Lancaster, Texas, United States

Hot Springs National Park, Arkansas, United States

Rio De Janeiro, Brazil

Kaohsiung City, Taiwan

Silver Spring, Maryland, United States

Nashik, India

Jinju Si, Korea, Republic Of

Dusit, Thailand

Berlin Zehlendorf, Germany

Przemysl, Poland

çankaya, Turkey

Ciudad De México, Mexico

Delhi, India

Angers, France

Buenos Aires, Argentina

Henrico, Virginia, United States

La Plata, Argentina

Varanasi, India

Yokohama, Japan

Braunschweig, Germany

Chengdu, China

Szklarska Poręba, Poland

łódź, Poland

Bury St Edmunds, United Kingdom

Guadalajara, Mexico

Caba, Argentina

London, United Kingdom

Fatih Istanbul, Turkey

Padua, Italy

Ciudad Autónoma De Buenos Aire, Argentina

Ciudad De Córdoba, Argentina

Avignon, France

Saint Malo, France

Pietermaritzburg, South Africa

İzmir, Turkey

Bengaluru, India

Kolkata, India

Caba, Argentina

Santa Cruz Do Sul, Brazil

Trois Rivières, Quebec, Canada

Hamburg, Germany

Naucalpan, Mexico

Nanchang, China

Horsham, Pennsylvania, United States

Denver, Colorado, United States

Sapporo Shi, Japan

Quimper, France

Calgary, Alberta, Canada

Linyi, China

Bengbu, China

Przemyśl, Poland

Matsuyama, Japan

Daegu, South Korea

Incheon, South Korea

Jinju, South Korea

Seoul, South Korea

Seoul, South Korea

Izmir, Turkey (Türkiye)

Cheongju Si, South Korea

Suwon, South Korea

Pamukkale, Turkey (Türkiye)

Seoul, South Korea

Kōtoku, Japan

Nuremberg, Germany

Antalya, Turkey (Türkiye)

Bunkyō City, Japan

Paris, France

Sendai, Japan

Warsaw, Poland

Suwon, South Korea

çankaya, Turkey (Türkiye)

Seoul, South Korea

Córdoba, Argentina

Antwerp, Belgium

Prague, Czechia

St Malo, France

Sakai, Japan

Sapporo, Japan

Culiacán, Mexico

Mexico City, Mexico

Banská Bystrica, Slovakia

Emanzimtoti, South Africa

Taoyuan District, Taiwan

Ankara, Turkey (Türkiye)

Diyarbakır, Turkey (Türkiye)

Fatih Istanbul, Turkey (Türkiye)

Istanbul, Turkey (Türkiye)

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported