Identification of a Pool of miRNA to Improve Early Management of Perinatal Asphyxia and Hypoxic Ischemic Encephalopathy

Launched by OSPEDALE BUON CONSIGLIO FATEBENEFRATELLI · Aug 3, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new way to help diagnose and manage a serious condition called hypoxic-ischemic encephalopathy (HIE), which can occur in newborns who don’t get enough oxygen during birth. HIE can lead to significant neurological problems, and researchers are looking for reliable markers in the blood that could help identify which babies are at risk and who might benefit from treatments like therapeutic hypothermia, a cooling therapy that can protect the brain. The study will compare levels of certain small molecules called microRNAs in healthy newborns and those with low oxygen levels, helping to assess their potential as helpful tools in treating HIE.

To participate in this trial, newborns need to be at least 35 weeks old and weigh at least 1800 grams. The trial is currently recruiting participants, and all genders are eligible. If a newborn is chosen, doctors will collect blood samples to measure the microRNAs and monitor their condition closely. This research aims to improve how we understand and treat newborns with oxygen deprivation, potentially leading to better outcomes for these vulnerable infants.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • newborns with at least 35 weeks of gestational age
• • body weight of at least 1800 g
• Exclusion Criteria:
• • Withdrawal of informed consent