Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of IOWI in Preventing SSIs in Emergency Laparotomies
Launched by DOW UNIVERSITY OF HEALTH SCIENCES · Aug 9, 2023
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying how effective two different methods of cleaning surgical wounds are in preventing infections after emergency surgeries called laparotomies. Specifically, it compares using a large amount of saline solution (a type of saltwater) to clean the wound versus using a solution called povidone-iodine, which is often used to disinfect skin. The researchers want to find out which method leads to fewer infections and whether it affects how long patients need to stay in the hospital after their surgery.
To participate in this trial, patients should be between 18 and 60 years old and must be having an emergency laparotomy at Dr. Ruth K. M. Pfau Civil Hospital in Karachi. However, some individuals cannot join the study, including those with diabetes, weakened immune systems, or recent abdominal surgeries. Participants will be randomly assigned to one of two groups: one group will receive saline irrigation before their wound is closed, while the other will have their wound closed without any irrigation. This trial is currently looking for volunteers to help improve surgical care and reduce the risk of infections.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • • Patients undergoing emergency laparotomy under the care of surgical-6 unit of Dr. Ruth K. M. Pfau Civil Hospital Karachi
- • The age of patients should be between 18-60 years old.
- Exclusion Criteria:
- • Diabetic patients
- • Immune-suppressed patients
- • Patients taking steroids
- • Patients undergoing chemo-radiotherapy.
- • Pregnant females
- • Previous abdominal surgery within the last 30 days.
- • Presence of concurrent abdominal wall infections.
- • Trauma Laparotomies
- • Large Bowel perforations
About Dow University Of Health Sciences
Dow University of Health Sciences (DUHS) is a premier educational and research institution based in Karachi, Pakistan, dedicated to advancing healthcare through innovative research and clinical excellence. As a clinical trial sponsor, DUHS integrates cutting-edge scientific inquiry with practical applications, fostering a collaborative environment that promotes the development of new treatments and therapies. The institution is committed to upholding the highest ethical standards in research, ensuring participant safety, and contributing to the global body of medical knowledge. With a focus on interdisciplinary collaboration and community health impact, DUHS plays a pivotal role in enhancing the quality of healthcare both locally and internationally.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Karachi, Sindh, Pakistan
Patients applied
Trial Officials
Omer Bin Khalid, Assist Prof.
Principal Investigator
Dr. Ruth F. M. Pfau Civil Hospital Karachi
Imrana Zulfikar, Professor
Study Director
Dr. Ruth F. M. Pfau Civil Hospital Karachi
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported