Evaluation of Circulating Neutrophils in Antisynthetase Syndrome

Launched by CENTRAL HOSPITAL, NANCY, FRANCE · Aug 4, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the role of a type of immune cell called neutrophils in patients with Antisynthetase Syndrome (ASyS), a rare condition that can cause muscle weakness, lung problems, and skin changes. Researchers want to find out if the level of circulating neutrophils (those found in the blood) can serve as a simple measure to determine how severe the disease is at diagnosis. They believe that higher levels of these neutrophils might indicate more serious symptoms and help predict how the disease will progress.

To participate in this study, patients need to have a confirmed diagnosis of ASyS, but those with active infections or certain types of cancer, or who have started steroid treatment before their neutrophil levels are measured, cannot join. If eligible, participants will have their neutrophil levels checked at diagnosis and again after one year of treatment to see how the levels change and what that might mean for their overall health. This trial could help improve how doctors understand and manage ASyS in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with ASyS diagnosis according to Connors criteria
• Exclusion Criteria:
• • Active infection at ASyS diagnosis
• • Evolutive cancer at ASyS diagnosis
• • Corticosteroid therapy initiation before circulating neutrophils evaluation