Long Term Outcome of Easophageal Atresia : Transmics Profiles in Adolescence

Launched by UNIVERSITY HOSPITAL, LILLE · Aug 8, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the long-term health outcomes of adolescents who were born with a condition called esophageal atresia, where the esophagus is not properly connected. The goal is to understand how this condition affects individuals as they grow up, particularly focusing on their health at ages 13 and 14. Researchers will collect clinical data and biological samples, like blood and tissue from the esophagus, to analyze and create a detailed profile of the condition's effects over time.

To participate in the study, you need to be between 13 and 14 years old and have been born with esophageal atresia, with a specific type of surgery performed to connect your esophagus. You should also be registered in a national database for this condition. Participants will undergo certain medical procedures, like an upper GI endoscopy, which is a way for doctors to look at the esophagus and take small samples for further study. This research aims to provide valuable insights into the ongoing health challenges faced by those with esophageal atresia and to improve care for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * For the oesophageal atresia group :
• • Born with oesophageal atresia (EA) in France or in French overseas departments and territories
• • Anastomosis performed
• • Included into the ReNaTo registry
• • Aged 13 or 14 during the recruitment period
• • Patient willing to comply with all study procedures and duration
• • Patient will social security
• For the blood sub-study :
• • Upper GI endoscopy performed as part of care between 13 and 14 years of age with esophageal mucosal biopsy sampling
• • Patient having given written consent to participate in the study
• For the control arm:
• • Upper GI endoscopy performed as part of care between 10 and 14 years of age with oesophageal mucosal biopsy sampling
• • Upper GI endoscopy performed as part of care for chronic or acute digestive signs to rule out organic etiology (peptic esophagitis, gastric esophagitis, eosinophilic esophagitis or ulcer)
• • Normal endoscopy and histology
• • No chronic progressive disease
• Exclusion Criteria:
• * For the oesophagal atresia arm :
• • Concurrent participation in an interventional trial and in the 3 months prior to inclusion
• • Parents refusing to participate in the study
• For the control arm :
• • Histologically non-normal esophageal biopsy
• • Parents refusing to participate in the study
• • Child with known organic pathology