Changes in Inhibition and Valuation After Eating

Launched by ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · Aug 15, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how eating affects decision-making and self-control in women with bulimia nervosa (BN). Researchers want to understand how the act of eating influences thoughts and feelings about control, which may contribute to the cycles of binge eating, purging, and restricting food intake that many individuals with BN experience. By learning more about these patterns, the goal is to find better ways to help treat bulimia nervosa.

Women aged 18 to 45 who are currently experiencing bulimia nervosa may be eligible to participate in this study. Participants should have a body mass index (BMI) between 18.5 and 30 and must be right-handed and English-speaking. During the study, participants will take part in activities related to eating and decision-making, while undergoing brain scans to help researchers gather important information. It’s also important to note that certain health conditions, pregnancy, and allergies to meal ingredients can affect eligibility for the trial.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Female
• • Aged 18 to 45 years
• • Current BMI greater than or equal to 18.5kg/m2 but under 30kg/m2
• • Right-handed
• • English-speaking
• Additional Inclusion Criteria for Women with Bulimia Nervosa:
• • Meet DSM-5 criteria for bulimia nervosa
• Exclusion Criteria:
• • Medical instability
• • Ongoing medical treatment, medical condition, or psychiatric disorder that may interfere with study variables or participation
• • Shift work
• • Pregnancy, planned pregnancy, or lactation during the study period
• • Allergy to any of the ingredients in or unwillingness to consume the standardized meal or unwillingness to drink water during the fasting period
• • Any contraindication for fMRI