Brain Neuronal Networks, Chemosensory and Trigeminal Functions in Allo-HSCT

Launched by UNIVERSITY OF OSLO · Aug 21, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how taste, smell, and certain sensations in the mouth and face are affected in patients who are undergoing a specific type of treatment called allogeneic hematopoietic stem cell transplantation (allo-HSCT). Researchers want to find out if this treatment can change the way people experience taste and smell, cause feelings like tingling or burning, and affect saliva production, which can lead to dry mouth and dental problems. They also aim to understand how these changes might be linked to the brain areas responsible for taste, smell, and pain.

To be part of this study, participants should be adults who are receiving this treatment for the first time and have been diagnosed with leukemia or a related condition. However, people with certain health issues affecting their mouth, brain, or immune system, as well as pregnant individuals, cannot participate. Those who join the study will help researchers learn more about the effects of this treatment on sensory functions, which could lead to better care and support for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • • patients receiving myeloablative conditioning for a first-time allo-HSCT and diagnosed with either a leukemia or a myelodysplastic syndrome
• Exclusion Criteria:
• • disorders affecting the oral cavity including poor tooth-status
• • those using drugs affecting the gustatory/olfactory functions
• • those with brain disorders
• • those who have a chronic disorder affecting the immune system, have cancer or who are pregnant.